Objective To analyze the pulmonary function, nutritional status and oxidative stress ability of patients with chronic obstructive pulmonary disease (COPD) in stable stage.
Methods A total of 65 COPD patients in our hospital were selected as experimental group, and another 35 healthy people as control group. The levels of adiponectin and pulmonary function were compared between the two groups. The nutritional assessment was performed by micronutrient assessment (MNA), and the levels of serum reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD) and total antioxidant capacity (TAC) were measured.
Results The level of adiponectin in the experimental group was significantly lower than that in the control group. The pulmonary function index such as ratio of forced expiratory volume in one second to predicted value(FEV1%), forced vital capacity(FVC) and ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC) in the experimental group were also significantly lower than those in the control group (P < 0.05). The nutritional status of all the participants in the control group was good. Among the 65 cases in the experimental group, 35 cases (53.85%) were well-nourished and 30 cases (46.15%) were malnourished. The total MNA score of the well-nourished participants in the experimental group was significantly higher than that of those with malnutrition (P < 0.05). The GSH, SOD and TAC of the experimental group were significantly lower, and MDA was higher than those of the control group(P < 0.05).
Conclusion The pulmonary function, nutritional status and oxidative stress ability of COPD patients in stable stage are closely related. Malnutrition may lead to in creased oxidative stress, which may lead to a decline in pulmonary function. Therefore, interventions should be taken to improve the nutritional status of COPD patients.
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