Change and significance of interleukin-17 and chemokine 10 in children with autoimmune hepatitis

  Objective  To explore the change and significance of interleukin-17(IL-17) and chemokine 10 (CXCL10) in children with autoimmune hepatitis.

  Methods  A total of 80 children with autoimmune hepatitis were selected as observation group, and 60 healthy children with physical examination in the same period were selected as control group. The relative biochemical indexes and the expressions of IL-17 and CXCL10 in serum were compared between two groups, and correlations between serum IL-17, CXCL10 and occurrence of autoimmune hepatitis were analyzed.

  Results  The levels of alanine aminotransferase (ALT), glutamate transaminase (AST), total bilirubin (TBIL), immunoglobulin (IgG), IL-17 and CXCL10 in the observation group were significantly higher than those in the control group (P < 0.05). The Pearson correlation analysis showed that serum IL-17 and CXCL10 were positively correlated with ALT, AST, TBIL and IgG (P < 0.05). There was a positive correlation between serum IL-17, CXCL10 and the occurrence of autoimmune hepatitis in children (r=0.634、0.592, P < 0.05). Logistic regression analysis showed that serum IL-17 and CXCL10 were the independent risk factors for autoimmune hepatitis in children (P < 0.05).

  Conclusion  The expressions of serum IL-17 and CXCL10 significantly increase in children with autoimmune hepatitis.