Objective To investigate the effect of aspirin combined with small dose clopidogrel on neurological function in elderly patients with cerebral infarction.
Methods Totally 120 elderly patients with cerebral infarction were selected and divided into two groups according to therapeutic regimens. The control group was treated with aspirin (100 mg), while the observation group was treated with aspirin (50 mg) plus small dose clopidogrel (25 mg). After 14 days of treatment, the neurological function, daily living ability, efficacy and incidence of adverse reactions before and after treatment were compared between two groups.
Results After treatment, the stroke scale (NIHSS) score of the observation group was significantly lower than that of the control group, and the score of Barthel rating scale (BI) was significantly higher than that of the control group (P < 0.05). The total effective rate of the observation group was 91.67%, which was significantly higher than 73.33% of the control group (P < 0.05). There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05).
Conclusion Aspirin combined with small dose clopidogrel is effective in the treatment of elderly patients with cerebral infarction, which can effectively promote the recovery of neurological function and improve daily living ability.
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