Effect of mean arterial pressure variability on N-terminal brain natriuretic peptide precursor and high-sensitivity C-reactive protein during internal fixation of lower limb fractures in the elderly patients

  Objective  To observe the mean arterial pressure variability of serum N-terminal brain natriuretic peptide precursor (NT-proBNP) and high-sensitivity C-reactive protein(hs-CRP) levels during internal fixation of lower limb fractures in the elderly patients.

  Methods  A total of 180 elderly patients with open reduction and internal fixation of lower extremity fractures were divided into three groups(coronary heart disease group, cerebral infarction group, coronary heart disease combined with cerebral infarction group). The changes of NT-proBNP and hs-CRP in serum were observed when basal mean arterial pressure, mean arterial pressure decreased by 5%, 10% and 20%, respectively, and their correlation was analyzed.

  Results  Serum NT-proBNP and hs-CRP increased with the decrease of mean arterial pressure, especially when the mean arterial pressure decreased more than 20%.

  Conclusion  The change of mean arterial pressure can reflect the changes of NT-proBNP and hs-CRP in patients, which indicates that the significantlyincreased possibility of cardio-cerebrovascular accident during operation.