Clinical value of serum homocysteine, cystatin C, urinary albumin and urinary β₂ microglobulin in diabetic nephropathy

  Objective  To investigate the value of serum homocysteine, cystatin C, urinary albumin, and urinary β₂ microglobulin in diabetic nephropathy.

  Methods  A total of 200 diabetic nephropathy patients in our hospital were randomly selected as research group. In the same period, 200 healthy subjects were selected as control group. Levels of serum homocysteine, cystatin C, urinary albumin, and urinary β₂ microglobulin were detected in both groups, and the differences between the two groups were compared.

  Results  The serum homocysteine, cystatin C, urinary albumin, and urinary β₂ microglobulin levels in the study group at diagnosis were higher than that in the control group at physical examination and after treatment(P < 0.05). The positive rate of combined detection of homocysteine, cystatin C, urinary albumin, and urinary β₂ microglobulin was 89.00%, which was higher than 49.50%, 65.00%, 57.00%, and 67.50%, respectively, of detection alone(P < 0.05).

  Conclusion  Clinical combineddetection of serum homocysteine, cystatin C, urinary albumin, and urinary β₂ microglobulin is helpful to improve the positive rate of diagnosis of diabetic nephropathy and guide the formulation of treatment plan.