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ZENG Yan, ZHANG Li, SHEN Hong, WANG Yong. Clinical value of serum homocysteine, cystatin C, urinary albumin and urinary β2 microglobulin in diabetic nephropathy[J]. Journal of Clinical Medicine in Practice, 2019, 23(11): 109-112. DOI: 10.7619/jcmp.201911031
Citation: ZENG Yan, ZHANG Li, SHEN Hong, WANG Yong. Clinical value of serum homocysteine, cystatin C, urinary albumin and urinary β2 microglobulin in diabetic nephropathy[J]. Journal of Clinical Medicine in Practice, 2019, 23(11): 109-112. DOI: 10.7619/jcmp.201911031
shu

Clinical value of serum homocysteine, cystatin C, urinary albumin and urinary β2 microglobulin in diabetic nephropathy

  • 1.

    Department of Clinical Laboratory, Shaanxi Friendship Hospital, Xi′an, Shaanxi, 710068

  • 2.

    Department of Clinical Laboratory, Xi′an Jiaotong University Hospital, Xi′an, Shaanxi, 710049

  • 3.

    Department of Clinical Laboratory, Xi′an North Vehicle Hospital, Xi′an, Shaanxi, 710086

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  • Received Date: March 19, 2019
  • Accepted Date: April 24, 2019
  • Available Online: February 22, 2021
  • Published Date: June 14, 2019
    Graphical Abstract
    • Abstract
  •   Objective  To investigate the value of serum homocysteine, cystatin C, urinary albumin, and urinary β2 microglobulin in diabetic nephropathy.
      Methods  A total of 200 diabetic nephropathy patients in our hospital were randomly selected as research group. In the same period, 200 healthy subjects were selected as control group. Levels of serum homocysteine, cystatin C, urinary albumin, and urinary β2 microglobulin were detected in both groups, and the differences between the two groups were compared.
      Results  The serum homocysteine, cystatin C, urinary albumin, and urinary β2 microglobulin levels in the study group at diagnosis were higher than that in the control group at physical examination and after treatment(P < 0.05). The positive rate of combined detection of homocysteine, cystatin C, urinary albumin, and urinary β2 microglobulin was 89.00%, which was higher than 49.50%, 65.00%, 57.00%, and 67.50%, respectively, of detection alone(P < 0.05).
      Conclusion  Clinical combineddetection of serum homocysteine, cystatin C, urinary albumin, and urinary β2 microglobulin is helpful to improve the positive rate of diagnosis of diabetic nephropathy and guide the formulation of treatment plan.
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    • References (18)
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