GU Zhangming, SUN Li. Influence of flupentixol and melitracen tablets combined with Shugan Jieyu Capsule on the efficiency and status of anxiety and depression in patients with refractory gastroesophageal reflux[J]. Journal of Clinical Medicine in Practice, 2019, 23(12): 32-35. DOI: 10.7619/jcmp.201912010
Citation: GU Zhangming, SUN Li. Influence of flupentixol and melitracen tablets combined with Shugan Jieyu Capsule on the efficiency and status of anxiety and depression in patients with refractory gastroesophageal reflux[J]. Journal of Clinical Medicine in Practice, 2019, 23(12): 32-35. DOI: 10.7619/jcmp.201912010

Influence of flupentixol and melitracen tablets combined with Shugan Jieyu Capsule on the efficiency and status of anxiety and depression in patients with refractory gastroesophageal reflux

More Information
  • Received Date: March 24, 2019
  • Accepted Date: May 18, 2019
  • Available Online: February 22, 2021
  • Published Date: June 27, 2019
  •   Objective  To investigate the clinical effect of flupentixol and melitracen tablets combined with Shugan Jieyu capsule on the treatment of patients with refractory gastroesophageal reflux disease (GERD).
      Methods  A total of 90 patients with refractory GERD were randomly divide into control group and research group, with 45 cases in each group. The control group was treated with lansoprazole enteric-coated capsules plus mosapride citrate, while the research group was treated with flupentixol and melitracen tablets (Delixin) and Shugan Jieyu Capsules on the basis of the control group. The scores of symptoms of GERD, Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were compared before treatment and 6, 12 weeks after treatment between two groups, and the clinical efficacy and safety was evaluated between two groups.
      Results  There was 1 case of dropout in the research group. The scores of Reflux Disease Questionnaire (RDQ), HAMD and HAMA in both groups at 6 and 12 weeks of treatment were significantly lower than those before treatment (P < 0.05), and these indexes of the research group at 6 and 12 weeks of treatment were significantly lower than those of the control group (P < 0.05). The total effective rate was 95.45% in the researchgroup, which was significantly higher than 80.00% in the control group (P < 0.05). There were only a few mild discomfort symptoms in the two groups during the treatment period.
      Conclusion  On the basis of routine PPI optimal treatment, flupentixol andmelitracen tablets combined with Shugan Jieyu Capsule can effectively relieve the clinical symptoms of refractory GERD and improve the mental state.
  • [1]
    李玉芳, 乔大伟, 肖云, 等. 胃食管反流病患者食管动力学特点及其诊治[J]. 实用医学杂志, 2018, 34(3): 490-492. doi: 10.3969/j.issn.1006-5725.2018.03.037
    [2]
    李意茹, 李亚, 牛春燕. 质子泵抑制剂在胃食管反流病中应用的研究进展[J]. 国际消化病杂志, 2018, 38(3): 170-173. doi: 10.3969/j.issn.1673-534X.2018.03.005
    [3]
    张伟, 仇明. 质子泵抑制剂与难治性胃食管反流病[J]. 中华胃食管反流病电子杂志, 2017, 4(3): 97-99. https://www.cnki.com.cn/Article/CJFDTOTAL-SDFL201703001.htm
    [4]
    钱本余, Fock K M, Talley N J, 等. 亚太地区胃食管反流病的处理共识: 更新版[J]. 胃肠病学, 2008, 13(7): 421-436. doi: 10.3969/j.issn.1008-7125.2008.07.010
    [5]
    陈旻湖, 侯晓华, 肖英莲, 等. 2014年中国胃食管反流病专家共识意见[J]. 胃肠病学, 2015, 20(3): 155-168. doi: 10.3969/j.issn.1008-7125.2015.03.007
    [6]
    王天佑, 郭子皓, 陈婧, 等. 胃食管反流病患者中胃食管连接部形态与24 h食管pH-阻抗监测及胃镜结果的相关性研究[J]. 胃肠病学和肝病学杂志, 2017, 26(8): 898-901. doi: 10.3969/j.issn.1006-5709.2017.08.015
    [7]
    肖茹萍, 陈阳, 卜平, 等. 难治性胃食管反流病与CYP2C19基因多态性的相关性研究[J]. 医学研究杂志, 2017, 46(11): 58-61. doi: 10.11969/j.issn.1673-548X.2017.11.015
    [8]
    陆清, 雷甜甜, 王一岚, 等. 难治性胃食管反流疾病的发病机制和治疗进展[J]. 四川医学, 2017, 38(10): 1212-1216. https://www.cnki.com.cn/Article/CJFDTOTAL-SCYX201710032.htm
    [9]
    耿华, 申青霞, 任顺平, 等. 从郁论治难治性胃食管反流病[J]. 中医药学报, 2018, 46(5): 78-80. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXB201805018.htm
    [10]
    陈晓仰. 汕头市功能性消化不良儿童情志、体格、家庭情况调查及发病危险因素与预防措施分析[J]. 中国妇幼保健, 2017, 32(17): 4242-4246. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201717075.htm
    [11]
    安万杰, 苏高建, 胡静. 枸橼酸莫沙必利分散片联合氟哌噻吨美利曲辛片治疗功能性消化不良的临床疗效观察[J]. 实用临床医药杂志, 2017, 21(21): 189-190. doi: 10.7619/jcmp.201721076
    [12]
    徐淑宁, 乔磊, 刘莺. 氟哌噻吨美利曲辛片联合解郁丸治疗肿瘤患者抑郁症的疗效观察[J]. 中国临床医生杂志, 2017, 45(9): 65-67. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLYS201709025.htm
    [13]
    李克建, 陈云, 郭娟, 等. 疏肝解郁胶囊联合草酸艾司西酞普兰治疗脑卒中患者焦虑抑郁状态的疗效观察[J]. 国际精神病学杂志, 2017, 44(2): 260-262, 266.
    [14]
    王奇, 戴小华. 舒肝解郁胶囊治疗冠心病PCI术后焦虑抑郁症研究进展[J]. 中西医结合心脑血管病杂志, 2017, 15(7): 820-822. doi: 10.3969/j.issn.1672-1349.2017.07.015
    [15]
    杨小艳, 郭传勇, 张旭, 等. 氟哌噻吨美利曲辛联合舒肝解郁胶囊治疗难治性胃食管反流病的疗效分析[J]. 中华医学杂志, 2017, 97(44): 3475-3479. doi: 10.3760/cma.j.issn.0376-2491.2017.44.008
  • Cited by

    Periodical cited type(14)

    1. 马杰,周平辉,李娜,张丽. 肠道训练技术在骨科腰椎滑脱术后卧床患者便秘中的应用研究. 南通大学学报(医学版). 2024(01): 97-99 .
    2. 赵晓茜,孙进宁,邢双双,杜长艳. 系统化康复训练对血液系统恶性肿瘤化疗患者便秘及相关症状的干预效果. 实用临床医药杂志. 2023(04): 117-122 . 本站查看
    3. 杨浩伦,薛建良,张黎明. 多体位按摩联合中频脉冲电以及超声波治疗急性阑尾炎穿孔术后不完全性肠梗阻一例. 华西医学. 2023(06): 952-953 .
    4. 赵佳丽,徐海虹,余旭彪. 针刺疗法联合康复训练改善腹腔镜结直肠癌根治术后胃肠功能临床研究. 新中医. 2023(18): 151-155 .
    5. 刘杰. 完全经肛单孔腹腔镜直肠全系膜切除术后排便功能康复训练护理效果. 中国实用医药. 2021(04): 201-203 .
    6. 琚会平. 循证护理干预对终末期恶性肿瘤合并肠梗阻患者肠道症状及生活质量的影响. 中国肛肠病杂志. 2020(01): 58-60 .
    7. 郑丽娜. 基于预见性理论的优质护理对肠梗阻患者术后感染的预防效果观察. 临床研究. 2020(05): 155-156 .
    8. 李丹丹. 1例老年女性不完全性肠梗阻合并肛门内括约肌痉挛收缩的护理. 临床医药文献电子杂志. 2020(16): 139 .
    9. 周宁. 一例胸12压缩性骨折合并功能性便秘患者肠道康复训练护理体会. 临床医药文献电子杂志. 2020(19): 166-167 .
    10. 牛琼亚. 快速康复护理对肠梗阻患儿术后胃肠功能及并发症的影响. 中国民康医学. 2020(07): 154-156 .
    11. 周凡,林晔,何巧珍,刘雪. 茶油胃管注入联合腹部按摩对成人不完全性肠梗阻的应用效果研究. 中国医学创新. 2020(30): 99-101 .
    12. 李玲燕. 医护一体化模式在温通抗癌方治疗不全性肠梗阻中的应用评价. 中国现代药物应用. 2019(11): 208-209 .
    13. 宋玉蓉. 粘连性不全性肠梗阻患者俯卧位护理干预的临床应用. 世界最新医学信息文摘. 2019(85): 18-19 .
    14. 梁毅. 便秘防治体操在预防中央束综合征便秘中的效果观察. 世界最新医学信息文摘. 2019(93): 352+360 .

    Other cited types(1)

Catalog

    Article views (470) PDF downloads (10) Cited by(15)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return