Changes of C reactive protein and serum procalcitoninin patients with severe acute pancreatitis

  Objective  To investigate the changes of C reactive protein (CRP) and procalcitonin (PCT) in patients with severe acute pancreatitis (SAP).

  Methods  Ninety patients with SAP were selected as SAP group, and 90 patients with mild acute pancreatitis were selected as MAP group, and 100 healthy people with physical examination were selected as control group. The CRP and PCT levels were detected in the three groups, and the combined diagnostic value of the two indexes was analyzed.

  Results  The serum levels of CRP and PCT were the highest in SAP group and the lowest in control group, and there were significant differences among three groups (P < 0.05). The declining area of ROC curve for serum PCT diagnosis was 0.87, and the optimum node was greater than or equal to 3 ng/mL. The declining area of ROC curve for serum CRP diagnosis was 0.79, and the optimum node was greater than or equal to 50 mg/L. For combination of two indexes, the negative likelihood ratio was 0.14, the positive likelihood ratio was 4.14, the accuracy was 88.20%, the specificity was 86.40%, and the sensitivity was 91.50%.

  Conclusion  CRP and serum PCT levels are positively correlated with the development of SAP, and the accuracy, specificity and sensitivity of the combined diagnosis of the two indicators are higher.