Investigation on adverse reactions of leukocyte-free blood transfusion and conventional blood transfusion

  Objective  To investigate the adverse reactions of leukocyte-free transfusion and conventional blood transfusion.

  Methods  The clinical data of 100 patients requiring blood transfusion were retrospectively analyzed. These patients were divided into observation group (leukocyte-free blood transfusion, n=50) and reference group (conventional blood transfusion, n=50) according to the random number table method. The adverse reactions after transfusion were compared between the two groups.

  Results  The incidence of adverse reactions such as fever and allergies in the observation group was significantly lower than that in the reference group (P < 0.05). Before transfusion, natural killer cells (NK cells) and T lymphocyte subsets (CD3⁺, CD4⁺, CD4⁺/CD8⁺), interleukin-2 (IL-2), interleukin-8 (IL-8), interleukin-10 (IL-10) and tumor necrosis factor-ɑ (TNF-ɑ) levels between the two groups showed no significant differences(P>0.05). After transfusion, the indicators of two groups all changed, but the observation group had significantly less change than the reference group (P < 0.05).

  Conclusion  Compared with conventional blood transfusion, leukocyte-free transfusion can reduce adverse reactions, reduce the inflammatory response caused by blood transfusion, and has less impact on the body′s immune suppression.