Efficiency observation of blood purification therapy combined with Shenfu Injection in treatment of patients with septic shock

  Objective  To investigate the effect of blood purification combined with Shenfu Injection in the treatment of septic shock.

  Methods  Totally 68 patients with septic shock were randomly divided into combined group and routine group, with 34 cases in each group. The routine group was treated by blood perfusion (HP) combined with continuous veno-venous hemofiltration (CVVH), and the combined group was treated with Shenfu Injection on the basis of routine group. The levels of inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), C reactive protein (CRP), procalcitonin (PCT) and vital signs Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ), mean arterial pressure (MAP), blood lactic acid (Lac), oxygenation index (OI) at different time points were compared between two groups, and levels of serum inflammatory cytokines were compared between survival and death patients.

  Results  After the first, second and third treatments, the levels of inflammatory cytokines in both groups were significantly lower than those before treatment, and the levels of inflammatory cytokines in the combined group were significantly lower than those in the routine group (P < 0.05). After the first, second and third treatments, the APACHE Ⅱ scores and Lac levels in both groups were significantly lower than those before treatment, the levels of MAP and OI were significantly higher than those before treatment, and APACHE Ⅱ scores, Lac levels and the levels of MAP and OI in the combined group were significantly better than those in the routine group (P < 0.05). The 28-day survival rate was 67.65% in the combined group and 58.82% in the routine group, which showed no significant difference (P>0.05). The levels of TNF-α, IL-10, CRP and PCT of survival patients in the combined group were significantly lower than those of survival patients in the routine group (P < 0.05). There were no significant differences in the above indexes in the died patients between the two groups (P > 0.05).

  Conclusion  Shenfu Injection combined with HP and CVVH can effectively reduce the levels of inflammatory cytokines in patients with septic shock, increase circulation blood volume of tissue, reduce the level of Lac, improve the prognosis of patients, and improve the survival rate of patients.