Effect of pulmonary surfactant combined with ventilator in treatment of neonatal meconium aspiration syndrome

ZHANG Binyu; WANG Hui; DU Yunyun

doi:10.7619/jcmp.201915014

Journal of Clinical Medicine in Practice > 2019 > 23(15): 53-55, 59. > DOI: 10.7619/jcmp.201915014

ZHANG Binyu, WANG Hui, DU Yunyun. Effect of pulmonary surfactant combined with ventilator in treatment of neonatal meconium aspiration syndrome[J]. Journal of Clinical Medicine in Practice, 2019, 23(15): 53-55, 59. DOI: 10.7619/jcmp.201915014

Citation:

PDF (664 KB)

Effect of pulmonary surfactant combined with ventilator in treatment of neonatal meconium aspiration syndrome

1.
Neonates Department, Ankang City Maternal and Child Health Care Hospital in Shaanxi Province, Ankang, Shaanxi, 725000
2.
Department of Pediatrics, Ziyang County People′s Hospital in Shaanxi Province, Ankang, Shaanxi, 725399

More Information

Received Date: May 09, 2019
Revised Date: June 27, 2019
Available Online: February 23, 2021
Published Date: August 14, 2019

Graphical Abstract

Abstract

Abstract

Objective To evaluate the clinical effect of pulmonary surfactant (PS) combined with ventilator in the treatment of neonatal meconium aspiration syndrome (MAS).
Methods A total of 200 children with MAS admitted to our hospital were randomly divided into control group (n=100) and observation group (n=100). The control group received ventilator treatment, and the observation group received PS treatment on the basis of the control group. The pulmonary oxygenation function and incidence of complication were compared between the two groups.
Results After treatment, the pulmonary oxygenation function and blood gas analysis indicators were improved compared with the control group; the mean airway pressure(MAP) and fraction of inspiration oxygen(FiO₂) were lower than that of the control group at 12 and 24 h after treatment. The application time of ventilator was shorter than that of the control group. The incidence of ventilator-associated pneumonia and lung air leakage as well as mortality were lower than that of the control group, there were significant differences in two groups (P < 0.05).
Conclusion PS combined with ventilator for MAS has ideal therapeutic efficacy, which can improve lung function, and reduce the incidence of complications.
- pulmonary surfactant,
- ventilator-associated pneumonia,
- neonatal meconium aspiration syndrome,
- pulmonary function,
- lung air leakage

FullText(HTML)

References (18)

References

[1]	郑秦, 邓春. 胎粪吸入综合征治疗进展[J]. 儿科药学杂志, 2016, 22(5): 58-61. https://www.cnki.com.cn/Article/CJFDTOTAL-EKYX201605022.htm
[2]	曹亚芹, 董玉斌, 张艳华, 等. 高频振荡通气治疗新生儿胎粪吸入综合症临床疗效分析[J]. 临床肺科杂志, 2018, 23(1): 175-177. doi: 10.3969/j.issn.1009-6663.2018.01.048
[3]	李春亮, 劳晓玲, 刘珍凤, 等. 手控高频持续正压通气转运新生儿重症胎粪吸入综合征[J]. 中国小儿急救医学, 2016, 23(10): 698-701. doi: 10.3760/cma.j.issn.1673-4912.2016.10.012
[4]	高晓燕, 冯琳, 邱玉芬, 等. 加温湿化高流量鼻导管通气在胎粪吸入综合征并肺动脉高压机械通气撤机中的应用研究[J]. 中国当代儿科杂志, 2017, 19(4): 393-397. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201704007.htm
[5]	陈超. 肺表面活性物质在新生儿肺部疾病中的应用进展[J]. 中国实用儿科杂志, 2003, 18(11): 651-654. doi: 10.3969/j.issn.1005-2224.2003.11.006
[6]	郑玉琼, 申川桥, 黄茂. 肺表面活性物质联合沐舒坦在新生儿胎粪吸入综合征中的应用[J]. 广西医科大学学报, 2018, 35(10): 118-121. https://www.cnki.com.cn/Article/CJFDTOTAL-GXYD201810028.htm
[7]	胡亚美, 江载芳. 诸福棠实用儿科学[M]. 北京: 人民卫生出版社, 2005: 464-466.
[8]	周晓光, 肖昕, 农绍汉. 新生儿机械通气治疗学[M]. 北京: 人民卫生出版社, 2004: 344-349.
[9]	王丽, 王秋月. 布地奈德联合肺表面活性物质气管内滴入治疗胎粪吸入综合征的临床效果[J]. 中国医药导报, 2018, 15(23): 73-76. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201823017.htm
[10]	郝莉霞, 王飞, 马晓鹏. 肺表面活性物质两种气管内给药方式治疗重症胎粪吸入综合征疗效比较[J]. 儿科药学杂志, 2016, 22(4): 19-22. https://www.cnki.com.cn/Article/CJFDTOTAL-EKYX201604008.htm
[11]	谭秀贞, 吴时光, 张建华, 等. 猪肺表面活性物质联合布地奈德混悬液气管内滴入治疗新生儿胎粪吸入综合征的疗效观察[J]. 中国当代儿科杂志, 2016, 18(12): 1237-1241. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201612011.htm
[12]	王娴, 姚宝珍. 重复使用肺表面活性物质治疗新生儿重症胎粪吸入综合征的临床研究[J]. 检验医学与临床, 2016, 13(4): 475-476. doi: 10.3969/j.issn.1672-9455.2016.04.015
[13]	黎敏, 刘润宁. 肺泡表面活性物质联合机械通气对胎粪吸入综合征患儿肺功能影响[J]. 现代仪器与医疗, 2017, 23(4): 119-120. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYI201704048.htm
[14]	樊晓艳, 薛梅, 胡毓华. 外源性肺表面活性物质气管内注射对胎粪吸入综合征的治疗作用及其机制[J]. 山东医药, 2017, 57(45): 48-50. doi: 10.3969/j.issn.1002-266X.2017.45.015
[15]	黄静, 林新祝, 郑直. 高频振荡通气联合肺表面活性物质治疗新生儿重型胎粪吸入综合征并发肺出血的临床研究[J]. 中国当代儿科杂志, 2016, 18(11): 1075-1079. doi: 10.7499/j.issn.1008-8830.2016.11.004
[16]	宋桂玲. 肺表面活性物质对新生儿重症胎粪吸入综合征炎症反应及氧合功能的影响[J]. 临床和实验医学杂志, 2016, 15(17): 1727-1730. doi: 10.3969/j.issn.1671-4695.2016.17.025
[17]	蒋惠芬, 赵勇, 王金秀. 肺表面活性物质联合肺保护通气策略治疗新生儿重型胎粪吸入综合征合并急性肺损伤的疗效观察[J]. 实用临床医药杂志, 2017, 21(21): 24-24. https://www.cnki.com.cn/Article/CJFDTOTAL-XYZL201721006.htm
[18]	陈夜, 彭好, 袁涛. 早期高频振荡通气联合肺表面活性物质治疗新生儿MAS的临床疗效[J]. 重庆医学, 2018, 47(4): 521-523. doi: 10.3969/j.issn.1671-8348.2018.04.026

Cited By

Cited by

Periodical cited type(7)

1.	廖育荣，陈玉珠，黄小倩. 基因芯片技术联合Xpert MTB/RIF检测对涂阴肺结核的诊断效能分析. 中国医药指南. 2025(06): 123-125 .
2.	李欣，朱小刚，骆敏霞. 菌阴活动性肺结核的多层螺旋CT影像学特征及诊断模型构建. 分子影像学杂志. 2024(01): 83-87 .
3.	孙桂英，倪晓艳. 痰涂片镜检、基因芯片技术及GeneXpert MTB/RIF对疑似肺结核患者的检测效能分析. 检验医学与临床. 2024(20): 3074-3078 .
4.	柯尊友，陶晓东，张秀军，孙金军，徐红丽. 分子生物学技术在耐多药/耐利福平结核病诊断中的应用进展. 浙江中西医结合杂志. 2024(11): 1073-1077 .
5.	韩东梅，来守永，李莉，顾勐. 多层螺旋CT在单发性肺结核空洞和肺癌空洞中的应用价值. 中外医学研究. 2023(09): 60-64 .
6.	章先，王继璇，丁伟勇，鲍建芳，李肖梁. 抗体芯片应用于真菌毒素多重检测的综合性实验设计. 实验技术与管理. 2023(05): 11-17 .
7.	梁志勇. T-SPOT.TB在涂阴活动性肺结核诊断中的临床价值. 罕少疾病杂志. 2023(09): 43-45 .

Other cited types(2)

Get Citation

PDF

XML

Article views (250) PDF downloads (3) Cited by(9)

Turn off MathJax

Article Contents

Abstract

References

Effect of pulmonary surfactant combined with ventilator in treatment of neonatal meconium aspiration syndrome

Abstract

References

Cited by

Periodical cited type(7)

Other cited types(2)

Catalog

Export File

Citation

Format

Content