Clinical significance of coagulation function, blood gasanalysis and serum serum amino terminal pro-brainnatriuretic peptide level in patients with chronicobstructive pulmonary disease

ZHANG Lei; WANG Yong

doi:10.7619/jcmp.201915019

Journal of Clinical Medicine in Practice > 2019 > 23(15): 71-74. > DOI: 10.7619/jcmp.201915019

ZHANG Lei, WANG Yong. Clinical significance of coagulation function, blood gasanalysis and serum serum amino terminal pro-brainnatriuretic peptide level in patients with chronicobstructive pulmonary disease[J]. Journal of Clinical Medicine in Practice, 2019, 23(15): 71-74. DOI: 10.7619/jcmp.201915019

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Clinical significance of coagulation function, blood gasanalysis and serum serum amino terminal pro-brainnatriuretic peptide level in patients with chronicobstructive pulmonary disease

ZHANG Lei¹,
WANG Yong^2, ,

1.
Department of Critical Care Medicine, Nanzheng District People′s Hospital, Hanzhong, Shaanxi, 723100
2.
Department of Internal Medicine, Zhashui County Hospital of Traditional Chinese Medicine in Shaanxi Province, Shangluo, Shaanxi, 711400

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Received Date: May 10, 2019
Revised Date: June 20, 2019
Available Online: February 23, 2021
Published Date: August 14, 2019

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Abstract

Abstract

Objective To investigate the clinical significance of coagulation function, blood gas analysis and serum amino terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with chronic obstructive pulmonary disease.
Methods A total of 120 patients with chronic obstructive pulmonary disease admitted to our hospital were divided into acute group and stable group, with 60 patients in per group. At the same time, another 60 healthy controls in the same period were as the control group. Coagulation function, blood gas analysis and serum NT-proBNP levels were measured in the three groups.
Results The thrombin time (APTT), fibrinogen (FBG)and D-dimmer (DD)in the acute group and the stable group were higher than those in the control group, and the acute group was higher than the stable group(P < 0.05). The oxygen partial pressure[p(O₂)] level, partial pressure of carbon dioxide[p(CO₂)] in the acute group and the stable group was higher than that in the control group. The level of p(O₂) in the acute group was lower, and the level of p(CO₂) was higher than that in the stable group (P < 0.05). The levels of serum NT-proBNP in the acute group and stable group were higher when compared with the control group, the level of serum NT-proBNP in the acute group was higher than that in the stable group (P < 0.05). NT-proBNP was positively correlated with coagulation function and p(CO₂), and was negatively correlated with p(O₂) (P < 0.05).
Conclusion Coagulation function, blood gas analysis and serum NT-proBNP level can effectively monitor the condition and monitor prognosis of chronic obstructive pulmonary disease, and it has higher clinical value.

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References (18)

References

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Clinical significance of coagulation function, blood gasanalysis and serum serum amino terminal pro-brainnatriuretic peptide level in patients with chronicobstructive pulmonary disease

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