Clinical significance of coagulation function, blood gasanalysis and serum serum amino terminal pro-brainnatriuretic peptide level in patients with chronicobstructive pulmonary disease

  Objective  To investigate the clinical significance of coagulation function, blood gas analysis and serum amino terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with chronic obstructive pulmonary disease.

  Methods  A total of 120 patients with chronic obstructive pulmonary disease admitted to our hospital were divided into acute group and stable group, with 60 patients in per group. At the same time, another 60 healthy controls in the same period were as the control group. Coagulation function, blood gas analysis and serum NT-proBNP levels were measured in the three groups.

  Results  The thrombin time (APTT), fibrinogen (FBG)and D-dimmer (DD)in the acute group and the stable group were higher than those in the control group, and the acute group was higher than the stable group(P < 0.05). The oxygen partial pressurep(O₂) level, partial pressure of carbon dioxidep(CO₂) in the acute group and the stable group was higher than that in the control group. The level of p(O₂) in the acute group was lower, and the level of p(CO₂) was higher than that in the stable group (P < 0.05). The levels of serum NT-proBNP in the acute group and stable group were higher when compared with the control group, the level of serum NT-proBNP in the acute group was higher than that in the stable group (P < 0.05). NT-proBNP was positively correlated with coagulation function and p(CO₂), and was negatively correlated with p(O₂) (P < 0.05).

  Conclusion  Coagulation function, blood gas analysis and serum NT-proBNP level can effectively monitor the condition and monitor prognosis of chronic obstructive pulmonary disease, and it has higher clinical value.