LIU Ming, HAN Bin, CHANG Hongxia. Effect of dezocine injection combined with dexmedetomidineon postoperative pain and quality of life in patients with advanced liver cancer[J]. Journal of Clinical Medicine in Practice, 2019, 23(17): 65-68. DOI: 10.7619/jcmp.201917018
Citation: LIU Ming, HAN Bin, CHANG Hongxia. Effect of dezocine injection combined with dexmedetomidineon postoperative pain and quality of life in patients with advanced liver cancer[J]. Journal of Clinical Medicine in Practice, 2019, 23(17): 65-68. DOI: 10.7619/jcmp.201917018

Effect of dezocine injection combined with dexmedetomidineon postoperative pain and quality of life in patients with advanced liver cancer

More Information
  • Received Date: July 21, 2019
  • Accepted Date: August 26, 2019
  • Available Online: February 28, 2021
  • Published Date: September 14, 2019
  •   Objective  To investigate the effect of dezocine injection combined with dexmedetomidine on the postoperative pain and quality of life in patients with advanced liver cancer.
      Methods  A total of 64 patients with advanced liver cancer were selected and randomly divided into experimental group and control group, with 32 cases in each group. The control group was anesthetized with remifentanil during operation, while the experimental group was anesthetized with dzocine combined with dexmedetomidine on the basis of the control group. The extubation time, recovery time, orientation recovery time and pain degrees at 2, 6 and 24 hours after operation were compared between two groups. The scores of dimensions of SF-36 before operation and 7 days after operation were compared between two groups. The incidence rate of adverse reactions within 24 hours after operation was compared between the two groups.
      Results  The Visual Analogue Scale (VAS) scores of the experimental group at 2, 6 and 24 hours after operation were significantly lower than those of the control group (P < 0.05). The extubation time, recovery time and orientation recovery time of the experimental group were significantly shorter than those of the control group (P < 0.05). Before operation, there were no significant differences in the scores of dimensions of SF-36 between the two groups (P>0.05). After operation, the scores of physical function, psychological function and life function increased significantly in both groups (P < 0.05), and the scores of dimensions of SF-36 in the experimental group were significantly higher than those in the control group (P < 0.05). The incidence of postoperative adverse reactions in the experimental group was significantly lower than that in the control group (P < 0.05).
      Conclusion  Dezocine injection combined with dexmedetomidine can significantly alleviate postoperative pain in patients with advanced liver cancer, shorten the recovery time and improve the quality of life.
  • [1]
    魏矿荣, 彭侠彪, 梁智恒, 等. 全球肝癌流行概况[J]. 中国肿瘤, 2015, 24(8): 621-630. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHLU201508001.htm
    [2]
    管晨滔, 魏文强. 肝癌防治研究进展[J]. 肝癌电子杂志, 2015, 2(2): 42-47. https://www.cnki.com.cn/Article/CJFDTOTAL-GADZ201502016.htm
    [3]
    元元, 王晶瑶, 苑方, 等. 瑞芬太尼痛觉过敏大鼠糖原合成酶激酶-3β表达水平的变化[J]. 中华医学杂志, 2012, 92(7): 435-439. doi: 10.3760/cma.j.issn.0376-2491.2012.07.002
    [4]
    郭永兰. VAS评分在腰椎间盘突出症术后护理中应用[J]. 交通医学, 2014, 28(4): 403-404. https://www.cnki.com.cn/Article/CJFDTOTAL-JTYX201404038.htm
    [5]
    陈善桂, 张正琴. 全麻恢复期患者选择气管拔管时机的探讨[J]. 临床护理杂志, 2012, 11(4): 45-46. doi: 10.3969/j.issn.1671-8933.2012.04.022
    [6]
    Yu J M, Sun H, Wu C, et al. The analgesic effect of ropivacaine combined with dexmedetomidine for incision infiltration after laparoscopic cholecystectomy[J]. Surg Laparosc Endosc Percutan Tech, 2016, 26(6): 449-454. doi: 10.1097/SLE.0000000000000325
    [7]
    Dong C S, Lu Y, Zhang J, et al. The optimal dose of dexmedetomidine added to an sufentanil-based analgesic regimen for postoperative pain control in spine surgery: A probit analysis study[J]. Medicine: Baltimore, 2016, 95(39): e4776. doi: 10.1097/MD.0000000000004776
    [8]
    黄国喜, 陈丹. 右美托咪定复合舒芬太尼对肝癌患者术中血液流变学及应激反应的影响分析[J]. 河北医药, 2016, 38(20): 3118-3120. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYZ201620020.htm
    [9]
    Cao J L, Pei Y P, Wei J Q, et al. Effects of intraoperative dexmedetomidine with intravenous anesthesia on postoperative emergence agitation/delirium in pediatric patients undergoing tonsillectomy with or without adenoidectomy: A CONSORT-prospective, randomized, controlled clinical trial[J]. Medicine: Baltimore, 2016, 95(49): e5566. doi: 10.1097/MD.0000000000005566
    [10]
    田金美, 郑文清, 沈健斌, 等. 右美托咪定复合七氟醚对老年患者开腹手术术后认知功能的影响[J]. 心脑血管病防治, 2017, 17(6): 475-477. doi: 10.3969/j.issn.1009-816x.2017.06.20
    [11]
    张稳稳, 张辉, 程伟, 等. 右美托咪定复合地佐辛超前镇痛对后腹膜腔镜手术患者瑞芬太尼输注后痛觉过敏的影响[J]. 徐州医学院学报, 2016, 36(11): 709-712. doi: 10.3969/j.issn.1000-2065.2016.11.003
    [12]
    张国庆, 华丽, 张国梁. 右美托咪定复合瑞芬太尼用于肺癌切除术后的镇痛效果及对机体免疫功能的影响[J]. 中国药房, 2016, 27(30): 4215-4217. doi: 10.6039/j.issn.1001-0408.2016.30.13
    [13]
    Nishimura L T, Auckburally A, Santilli J, et al. Effects of dexmedetomidine combined with commonly administered opioids on clinical variables in dogs[J]. Am J Vet Res, 2018, 79(3): 267-275. doi: 10.2460/ajvr.79.3.267
    [14]
    金娟新, 王瑜, 潘敏珠. 不同剂量右美托咪复合地佐辛凯纷在子宫全切术后患者自控静脉镇痛中的对比[J]. 中国性科学, 2016, 25(1): 44-47. https://www.cnki.com.cn/Article/CJFDTOTAL-XKXZ201601015.htm
    [15]
    谢泽荣, 罗艳丽, 肖凤鸣. 肝癌患者行肝脏离断和门静脉结扎二步肝切除术的个性化护理[J]. 现代中西医结合杂志, 2016, 25(36): 4096-4098. doi: 10.3969/j.issn.1008-8849.2016.36.040
    [16]
    吕桂帅, 陈磊, 王红阳. 我国肝癌研究的现状与前景[J]. 生命科学, 2015, 27(3): 237-248. https://www.cnki.com.cn/Article/CJFDTOTAL-SMKX201503002.htm
    [17]
    麻姗姗. 帕瑞昔布钠预防瑞芬太尼痛觉过敏的临床观察[J]. 中国医师杂志, 2012(4): 549-551. doi: 10.3760/cma.j.issn.1008-1372.2012.04.045
    [18]
    万永灵, 陈学钧, 林涛, 等. 右美托咪定联合地佐辛对剖胸手术后拔管期血流动力学及镇痛镇静的影响[J]. 中国药房, 2013, 24(38): 3616-3618. doi: 10.6039/j.issn.1001-0408.2013.38.23
    [19]
    于学超. 地佐辛复合不同剂量右美托咪啶在术后静脉镇痛中的应用[J]. 天津医药, 2013, 41(9): 917-918. doi: 10.3969/j.issn.0253-9896.2013.09.023
    [20]
    廖琼, 张红. 右美托咪定与地佐辛对全身麻醉患者苏醒期躁动及血流动力学的影响[J]. 河北医学, 2015, 21(3): 389-392. doi: 10.3969/j.issn.1006-6233.2015.03.012
  • Cited by

    Periodical cited type(13)

    1. 毛振洲,李繁,张哲哲,冯宇,马东阳. 帕瑞昔布钠联合地佐辛对腹腔镜胃癌术后患者胃肠功能和镇痛效果的影响. 贵州医科大学学报. 2023(02): 239-243 .
    2. 盖殿秀,李铭. 右美托咪定与丙泊酚在经皮穿刺肝癌介入术中的麻醉价值研究. 中国实用医药. 2023(10): 115-117 .
    3. 和海波,李凤群. 地佐辛注射液对全身麻醉苏醒后疼痛度、体征指标影响. 中外医学研究. 2022(07): 144-146 .
    4. 符培栋. 地佐辛联合丙帕他莫治疗肾绞痛临床观察. 中国处方药. 2022(05): 104-105 .
    5. 崔建宁,史小凤,杨向霞. 地佐辛对于老年患者全麻苏醒期躁动的影响研究. 宁夏医学杂志. 2022(07): 649-651 .
    6. 何慧娟,漆勇,李萍,毕兴华,刘礼霞. 右美托咪定复合全身麻醉对肝癌切除术患者麻醉效果和血流动力学的影响研究. 中国现代医生. 2021(09): 129-133 .
    7. 白全召,张宁宁. 右美托咪定在老年患者无痛胃肠镜检查中的应用效果. 中国实用医刊. 2021(18): 69-71 .
    8. 张寅珠. 康复护理对肝癌终末期患者生活质量的影响. 中国医药指南. 2021(31): 22-24 .
    9. 潘正举,莫品军,谭健,刘璐,蒙兴虹. 地佐辛与瑞芬太尼用于经腹腔镜直肠癌根治手术中麻醉镇痛的效果. 中国现代医生. 2021(26): 142-145 .
    10. 梁俊迪,全毅,陈郁芬. 止痛药联合认知干预对肝癌患者术后生活质量的影响. 医学食疗与健康. 2021(11): 41-42 .
    11. 王华. 基于SFA模式的静脉自控镇痛对老年腹腔镜肝癌切除术后的效果观察. 中国疗养医学. 2020(10): 1105-1107 .
    12. 赵婷,安慎通. 右美托咪定联合七氟烷吸入麻醉对肝癌患者切除术后胃肠道功能的影响. 中国肿瘤临床与康复. 2020(09): 1061-1063 .
    13. 谢文昆,冯春善,覃家茂,黄英武,许金剑,吴佩华,覃荣昌,梁晨,农月芳. 快速康复外科理念在腹腔镜肝切除术中的应用价值. 微创医学. 2020(05): 699-701 .

    Other cited types(0)

Catalog

    Article views (231) PDF downloads (5) Cited by(13)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return