Objective To analyze the effect of concurrent chemoradiothrapy on the squamous cell carcinoma antigen (SCC-Ag) and carcinoembryonic antigen (CEA)levels in patients with intermediate-advanced cervical cancer.
Methods Totally 80 patients with intermediate-advanced cervical cancer were selected and divided into control group (n=40) and study group (n=40) according to the ways of chemoradiothrapy. The control group was given sequential chemoradiothrapy, and the study group was given concurrent chemoradiothrapy. The SCC-Ag and CEA levels and prognosis were compared between the two groups.
Results The total effective rate was 92.5% in the study group, which was significantly higher than 75.0% in the control group (P < 0.05). Compared with the control group, the levels of platelets, granulocytes, white blood cells and hemoglobin in the study group were significantly higher at 4 weeks after radiotherapy (P < 0.05). Compared with the control group, the SCC-Agand CEA levels in the study group were significantly lower at 4 weeks after radiotherapy (P < 0.05).
Conclusion Concurrent chemoradiothrapy is effective in the treatment of intermediate-advanced cervical cancer, which can alleviate toxic and side effects.
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