JING Zhiqiang, WEI Weiqiang, ZHANG Yanting, LI Lei. Efficiency analysis of Qingyi Chengqi Decoction combined with heterozygous blood purification in treating patients with acute severe pancreatitis[J]. Journal of Clinical Medicine in Practice, 2019, 23(18): 49-53. DOI: 10.7619/jcmp.201918015
Citation: JING Zhiqiang, WEI Weiqiang, ZHANG Yanting, LI Lei. Efficiency analysis of Qingyi Chengqi Decoction combined with heterozygous blood purification in treating patients with acute severe pancreatitis[J]. Journal of Clinical Medicine in Practice, 2019, 23(18): 49-53. DOI: 10.7619/jcmp.201918015

Efficiency analysis of Qingyi Chengqi Decoction combined with heterozygous blood purification in treating patients with acute severe pancreatitis

More Information
  • Received Date: June 14, 2019
  • Accepted Date: August 24, 2019
  • Available Online: February 28, 2021
  • Published Date: September 27, 2019
  •   Objective  To analyze the efficacy of Qingyi Chengqi Decoction combined with heterozygous blood purification in the treatment of patients with acute severe pancreatitis (ASP).
      Methods  Eighty-six patients with ASP were randomly divided into two groups, with 43 cases in each group. The control group was treated with heterozygous blood purification, while the observation group was given Qingyi Chengqi Decoction combined with heterozygous blood purification. Total effective rate, indicators of symptoms and signs improvement [abdominal pain disappearance time, time of blood amylase (AMS) return to normal, time of white blood cell recovery], hospitalization time, serum AMS level, intra-abdominal pressure (IAP), serum inflammation factors [C-reactive protein (CRP), tumor necrosis factor-α (TNF-α)] levels were compared between two groups.
      Results  The total effective rate of the observation group was 93.02%, which was significantly higher than 72.09% of the control group (P < 0.05). The disappearance time of abdominal pain, the time of blood AMS return to normal, the time of white blood cell recovery and the hospitalization time in the observation group were significantly shorter than those in the control group (P < 0.05). Serum AMS and IAP levels at 1, 3 and 5 days after treatment in the observation group were significantly lower than those in the control group (P < 0.05). The serum CRP and TNF-α levels at 1, 3 and 5 days after treatment in the observation group were significantly lower than those in the control group (P < 0.05).
      Conclusion  Qingyi Chengqi Decoction combined with heterozygous blood purification can effectively control the inflammatory reaction of ASP patients, alleviate the clinical symptoms and shorten the hospital stay.
  • [1]
    Jacob A O, Stewart P, Jacob O. Early surgical intervention in severe acute pancreatitis: Central Australian experience[J]. Anz JSurg, 2016, 86(10): 805-810. doi: 10.1111/ans.12707/abstract
    [2]
    Bielesz B O, Hecking M, Plischke M, et al. Correlations and Time Course of FGF23 and Markers of Bone Metabolism in Maintenance Hemodialysis Patients[J]. ClinBiochem, 2014, 47(13/14): 1316-1329. http://europepmc.org/abstract/MED/24956265
    [3]
    Chua T Y, Walsh R M, Baker M E, et al. Necrotizing pancreatitis: Diagnose, treat, consult[J]. Cleve Clin J Med, 2017, 84(8): 639-648. doi: 10.3949/ccjm.84a.16052
    [4]
    中华中医药学会脾胃病分会. 急性胰腺炎中医诊疗专家共识意见[J]. 中华中医药杂志, 2013, 28(6): 1826-1831. https://www.cnki.com.cn/Article/CJFDTOTAL-LCGD201711002.htm
    [5]
    中华医学会消化病学分会胰腺疾病学组. 中国急性胰腺炎诊治指南(2013, 上海)[J]. 中华胰腺病杂志, 2013, 13(7): 73-78. https://www.cnki.com.cn/Article/CJFDTOTAL-SYNK201307012.htm
    [6]
    中华医学会消化病学分会胰腺疾病学组. 中国急性胰腺炎诊治指南(2013年, 上海)[J]. 中华消化杂志, 2013, 29(9): 656-660. https://www.cnki.com.cn/Article/CJFDTOTAL-SYNK201307012.htm
    [7]
    Kitamura K, Horibe M, Sanui M, et al. The Prognosis of Severe Acute Pancreatitis Varies According to the Segment Presenting With Low Enhanced Pancreatic Parenchyma on Early Contrast-Enhanced Computed Tomography: A Multicenter Cohort Study[J]. Pancreas, 2017, 46(7): 867-873. doi: 10.1097/MPA.0000000000000851
    [8]
    Zhang X X, Deng L H, Chen W W, et al. Circulating microRNA 216 as a Marker for the Early Identification of Severe Acute Pancreatitis[J]. AmJMedSci, 2017, 353(2): 178-186. http://www.ncbi.nlm.nih.gov/pubmed/28183420
    [9]
    Tomkötter L, Erbes J, Trepte C, et al. The Effects of Pancreatic Microcirculatory Disturbances on Histopathologic Tissue Damage and the Outcome in Severe Acute Pancreatitis[J]. Pancreas, 2016, 45(2): 248-253. doi: 10.1097/MPA.0000000000000440
    [10]
    Merza M, Hartman H, Rahman M, et al. Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice with Severe Acute Pancreatitis[J]. Gastroenterology, 2015, 149(7): 1920-1931. doi: 10.1053/j.gastro.2015.08.026
    [11]
    Gao X F, Li J D, Guo L, et al. Effect of Hybrid Blood Purification Treatment on Secondary Hyperparathyroidism for Maintenance Hemodialysis Patients[J]. Blood Purif, 2018, 46(1): 19-26. doi: 10.1159/000486844
    [12]
    Bottari G, Taccone F S, Moscatelli A. Hybrid blood purification strategy in pediatric septic shock[J]. CritCare, 2016, 20(1): 366-373. http://europepmc.org/articles/PMC5103482
    [13]
    刘云峰, 李琳琳, 姚金锋, 等. 杂合式血液净化序贯治疗重症急性胰腺炎的时机选择[J]. 河北医药, 2016, 38(15): 2292-2295. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYZ201615015.htm
    [14]
    高咏梅, 杨婕琳, 刘云峰, 等. 杂合式血液净化序贯治疗重症急性胰腺炎的疗效观察[J]. 河北医科大学学报, 2016, 37(8): 953-956. doi: 10.3969/j.issn.1007-3205.2016.08.021
    [15]
    Bonesi M, Loizzo M R, Acquaviva R, et al. Anti-inflammatory and Antioxidant Agents from Salvia Genus (Lamiaceae): An Assessment of the Current State of Knowledge[J]. Antiinflamm Antiallergy Agents Med Chem, 2017, 16(2): 70-86. http://www.ncbi.nlm.nih.gov/pubmed/28464779
    [16]
    Zhang X M, Ma P A, Sun J W, et al. Effect of Qingyi Chengqi Decoction on severe acute pancreatitis patients: a clinical study[J]. Zhongguo Zhong XI Yi Jie He Za Zhi, 2014, 34(1): 31-34. http://europepmc.org/abstract/med/24520783
    [17]
    Ovadje P, Ammar S, Guerrero J A, et al. Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways[J]. Oncotarget, 2016, 7(45): 73080-73100. doi: 10.18632/oncotarget.11485
    [18]
    Ismail O Z, Bhayana V. Lipase or amylase for the diagnosis of acute pancreatitis[J]. Clinbiochem, 2017, 50(18): 1275-1280. http://www.sciencedirect.com/science/article/pii/S0009912017303569
    [19]
    Smit M, Buddingh K T, Bosma B, et al. Abdominal Compartment Syndrome and Intra-abdominal Ischemia in Patients with Severe Acute Pancreatitis[J]. World JSurg, 2016, 40(6): 1454-1461. doi: 10.1007/s00268-015-3388-7
    [20]
    Stirling A D, Moran N R, Kelly M E, et al. The predictive value of C-reactive protein (CRP) in acute pancreatitis - is interval change in CRP an additional indicator of severity[J]. HPB (Oxford), 2017, 19(10): 874-880. doi: 10.1016/j.hpb.2017.06.001
    [21]
    Mo X J, Ye X Z, Li Y P. Effects of euphorbia kansui on the serum levels of IL-6, TNF-α, NF-κB, sTNFR and IL-8 in patients with severe acute pancreatitis[J]. J Biol Regul Homeost Agents, 2019, 33(2): 469-475. http://www.ncbi.nlm.nih.gov/pubmed/30945511
    [22]
    黄定鹏, 陈健, 赵亚刚, 等. 加味大承气汤联合西药对急性胰腺炎患者疗效、微炎性反应状态、血清淀粉酶及血清钙影响[J]. 世界中医药, 2016, 11(11): 2259-2262. doi: 10.3969/j.issn.1673-7202.2016.11.013
    [23]
    罗新军, 穆恒, 张佩, 等. 承气清胰汤治疗急性胰腺炎临床疗效及对胃肠功能的影响[J]. 陕西中医, 2017, 38(11): 1507-1508. doi: 10.3969/j.issn.1000-7369.2017.11.009
    [24]
    高媛. 清胰承气汤治疗急性重症胰腺炎的临床观察及对炎症因子的影响[J]. 中国中医急症, 2017, 26(6): 1080-1082. doi: 10.3969/j.issn.1004-745X.2017.06.047
    [25]
    闫风. 清胰承气汤联合西药治疗重症急性胰腺炎患者的有效性观察[J]. 实用中西医结合临床, 2019, 19(1): 20-22. https://www.cnki.com.cn/Article/CJFDTOTAL-SZXL201901009.htm

Catalog

    Article views (213) PDF downloads (4) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return