Effect of transurethral plasma bipolar resection of prostate on urodynamics and serum levels of prostate specific antigen, epidermal growth factor and prostaglandin E₂ in patients with benign prostatic hyperplasia

  Objective  To explore the effects of transurethral plasma bipolar resection of prostate on urodynamics and serum levels of prostate specific antigen (PSA), epidermal growth factor (EGF) and prostaglandin E₂ (PGE₂) in patients with benign prostatic hyperplasia (BPH).

  Methods  Totally 150 patients with BPH were selected and divided into experimental group (n=76) and control group (n=74) according to treatment schemes. The control group was treated with transurethral vaporization resection of the prostate, and the experimental group was treated with transurethral plasma bipolar resection of the prostate. The levels of serum PSA, EGF and PGE₂ were compared between the two groups before treatment and 1 week after operation. The patients were followed up for 6 months. The urodynamic indexes residual urine volume (PVR), maximum urinary flow rate (Q_max), bladder compliance (BC), International Prostate Symptom Score (IPSS) and quality of life score (SF-36) were compared before treatment and 6 months after operation.

  Results  There was no significant difference in operation time between the two groups (P>0.05). The bleeding volume, VAS score at 3 days after operation in the experimental group were significantly lower than those in the control group, and the indwelling time of urinary catheter and hospitalization time were significantly shorter than those in the control group (P < 0.05). The incidence rate of complications in the experimental group was 7.89%, which was significantly lower than 25.68% in the control group (P < 0.05). The levels of serum PSA, EGF and PGE₂ in the first week after operation were significantly lower than those before operation in both groups, and those in the experimental group were significantly lower than the control group (P < 0.05). Six months after operation, the levels of PVR, Q_max and BC in both groups significantly improved when compared with those before operation, and those in the experimental group were significantly better than the control group (P < 0.05). Six months after operation, IPSS and SF-36 scores in both groups significantly improved when compared with those before operation, and those in the experimental group were significantly better than the control group (P < 0.05).

  Conclusion  Transurethral plasma bipolar resection of prostate can reduce surgical trauma, reduce incidence of complications, improve urodynamics, reduce serum levels of PSA, EGF and PGE₂, and improve quality of life.