Objective To explore the effect of two traditional Chinese medicine preparations with salvia miltiorrhiza as the main ingredient in the treatment of myocardial ischemia.
Methods A total of 104 coronary heart disease patients with myocardial ischemia were randomly divided into treatment A group and treatment B group, with 52 cases in each group. The patients of two groups were all given symptomatic treatment of conventional western medicine, group A was additionally treated with salvia miltiorrhiza injection while group B was additionally treated with sodium tanshinone ⅡA sulfonate injection, the treatment of two groups lasted for 4 weeks. The degree of ST segment decrease, changes of ischemic attack times and duration before and after treatment were observed, and the changes of electrocardiogram, clinical efficacy and safety of the two groups were compared.
Results After treatment, the range of ST segment decrease, frequency and duration of ischemic attacks decreased significantly in both groups (P < 0.05). Compared with group B, and group A decreased more significantly (P < 0.05). The total effective rate of electrocardiogram, and clinical total effective rate in group A were 90.38%, 92.31%, respectively, which were higher than 75.00%, 76.92%, respectively, in group B(P < 0.05). The incidence of adverse reactions of group A and group B were 9.62% and 7.69%, respectively, but there was no significant difference between the two groups (P>0.05).
Conclusion Salvia miltiorrhiza injection and sodium tanshinone ⅡA sulfonate injection play an important role in improving myocardial ischemia of coronary heart disease, but the former has better efficacy than the latter one.
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