Effect of parecoxib sodium versus flurbiprofenaxetil in analgesia after thymectomy for patients with myasthenia gravis

  Objective  To compare the effect of parecoxib sodium versus flurbiprofen axetil in analgesia after thymectomy for patients with myasthenia gravis.

  Methods  A total of 118 patients undergoing thymectomy for patients with myasthenia gravis were selected as the study subjects. According to the different ways of postoperative analgesia, they were divided into group A (60 cases) and group B (58 cases). The control group received intravenous drip of flurbiprofen axetil slowly after operation, while the observation group received intravenous drip of parecoxib sodium after the operation. The VAS scores of two groups at 1, 2, 6, 12 h of resting and exercising after operation were observed. The mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR), blood oxygen saturation (SpO₂) and occurrence of adverse reactions were observed at 1, 2, 6, 12 and 24 h before and after operation.

  Results  There were significant differences at different time points at rest and exercising in VAS scores in the same group (P < 0.05), and the observation group was significantly higher than that in the control group in above time points(P < 0.05). The levels of MAP, HR, RR at different time points in the same group showed significant difference(P < 0.05), but showed no between-group difference (P>0.05). The incidence of postoperative adverse reactions in observation group was significantly lower than that in control group (P < 0.05).

  Conclusion  Parecoxib sodium has a significant effect in analgesia after thymectomy for patients with myasthenia gravis.