Efficiency observation of Compound Danshen Dropping Pills, Mingmu Dihuang Pills and calcium dobesilate capsules in treating patients with diabetic retinopathy at stage Ⅲ

HU Xiaoli; LI Manhong; CHE Hongfang

doi:10.7619/jcmp.201919026

Journal of Clinical Medicine in Practice > 2019 > 23(19): 96-99. > DOI: 10.7619/jcmp.201919026

HU Xiaoli, LI Manhong, CHE Hongfang. Efficiency observation of Compound Danshen Dropping Pills, Mingmu Dihuang Pills and calcium dobesilate capsules in treating patients with diabetic retinopathy at stage Ⅲ[J]. Journal of Clinical Medicine in Practice, 2019, 23(19): 96-99. DOI: 10.7619/jcmp.201919026

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Efficiency observation of Compound Danshen Dropping Pills, Mingmu Dihuang Pills and calcium dobesilate capsules in treating patients with diabetic retinopathy at stage Ⅲ

1.
Department of Fundus Surgery, Xi′an Aier Eye Hospital, Xi′an, Shaanxi, 710000
2.
Department of Ophthalmology, Xijing Hospital, Xi′an, Shaanxi, 710032
3.
Department of Ophthalmology, Shaanxi Provincial Rehabilitation Hospital, Xi′an, Shaanxi, 710065

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Received Date: July 14, 2019
Accepted Date: September 12, 2019
Available Online: February 28, 2021
Published Date: October 14, 2019

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Abstract

Abstract

Objective To explore the clinical effect of Compound Danshen Dripping Pills, Mingmu Dihuang Pills and calcium dobesilate capsules in the treatment of patients with diabetic retinopathy (DR) at stage Ⅲ.
Methods Totally 76 patients (76 eyes) with DR at stage Ⅲ were randomly divided into two groups. In the control group, 35 patients were treated with calcium dobesilate capsules on the basis of routine treatment. In the study group, 41 patients were treated with Danshen Dripping Pills and Mingmu Dihuang Pills on the basis of control group. The therapeutic effect, bleeding spot area, visual gray value, hemangioma volume and macular thickness before and after treatment were compared between the two groups. The expression levels of vascular endothelial growth factor (VEGF), retinol binding protein 4 (RBP4) and insulin growth factor-1 (IGF-1) were compared between the two groups before and after treatment.
Results The clinical effect of the study group was significantly better than that of the control group (P < 0.05). After treatment, the hemorrhagic plaque area, hemangioma volume and macular thickness in the study group were significantly smaller than those in the control group, and the visual gray value and logMAR visual acuity were significantly lower than those in the control group (P < 0.05). After 1, 2 and 3 months of treatment, the serum levels of VEGF, RBP4 and IGF-1 in both groups showed a significant downward trend (P < 0.05), and the above indexes in the study group were significantly lower than those in the control group (P < 0.05).
Conclusion Combination of compound Danshen dropping pills, Mingmu Dihuang pills and calcium dobesilate are effective in the treatment of patients with DR at stage Ⅲ, which can effectively inhibit the angiogenesis mediated by various cytokines in retina, improve fundus symptoms and visual acuity of patients.

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Efficiency observation of Compound Danshen Dropping Pills, Mingmu Dihuang Pills and calcium dobesilate capsules in treating patients with diabetic retinopathy at stage Ⅲ

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