Quality method versus enzyme activity method in detection of serum lipoprotein-associated phospholipase A2 in cardiovascular and cerebrovascular diseases

SONG Laichun

doi:10.7619/jcmp.201920019

Journal of Clinical Medicine in Practice > 2019 > 23(20): 70-73. > DOI: 10.7619/jcmp.201920019

SONG Laichun. Quality method versus enzyme activity method in detection of serum lipoprotein-associated phospholipase A2 in cardiovascular and cerebrovascular diseases[J]. Journal of Clinical Medicine in Practice, 2019, 23(20): 70-73. DOI: 10.7619/jcmp.201920019

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Quality method versus enzyme activity method in detection of serum lipoprotein-associated phospholipase A2 in cardiovascular and cerebrovascular diseases

SONG Laichun

Laboratory Department, Liaocheng Third People′s Hospital, Liaocheng, Shandong, 252000

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Received Date: August 12, 2019
Revised Date: September 14, 2019
Available Online: February 28, 2021
Published Date: October 27, 2019

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Abstract

Abstract

Objective To explore the clinical value of serum lipoprotein-associated phospholipase A2(Lp-PLA2)detected by quality method in cardiovascular and cerebrovascular diseases.
Methods A total of 38 patients confirmed as acute myocardial infarction undergoing angiography, 29 cases with acute cerebral infarction, and 76 healthy cases with physical examinations were selected. Serum was collected and their Lp-PLA2 levels were detected by quality method and enzyme activity method to analyze their diagnostic efficacy.
Results In the acute myocardial infarction group, 36 cases were positive and 2 cases were negative by quality method, with a positive rate of 94.74%. A total of 35 cases were positive and 3 cases were negative by enzyme activity method, with a positive rate of 92.11%. The area under the ROC curve of the two detection methods was 0.851 and 0.846, respectively. In the acute cerebral infarction group, 24 cases were positive and 5 cases were negative by quality method, with a positive rate of 82.76%. Two cases were positive and 27 cases were negative by enzyme activity method, with a positive rate of 6.90%. The area under the ROC curve of the two detection methods was 0.784 and 0.101, respectively. All the 76 cases in the healthy group were negative. There was no statistical difference between the two methods in the detection of acute myocardial infarction (P>0.05), but a significant difference was seen in the detection of acute cerebral infarction (P < 0.05).
Conclusion The detection of serum Lp-PLA2 by mass method has high specificity and accuracy in the diagnosis of acute myocardial infarction and acute cerebral infarction, which can be used as a diagnosis for acute myocardial infarction and acute cerebral infarction and makes up the limitations of angiography.

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