Detection of indicators for patients with acute left ventricular failure complicated with pulmonary infection and and its diagnostic value

  Objective  To detect the levels of serum C-reactive protein (CRP), procalcitonin (PCT), type B natriuretic peptide (BNP) and high sensitive troponin T (hs-cTnT) in patients with acute left heart failure complicated with pulmonary infection, and its diagnostic value.

  Methods  A total of 80 patients with acute left heart failure admitted to our hospital were divided into non-infectious group (n=38) without pulmonary infection and infectious group (n=42) with pulmonary infection according to the clinical manifestations and laboratory results. Eighty healthy volunteers who underwent health examination in our hospital at the same time were selected as control group (n=80). The levels of serum inflammatory factors such as CRP, PCT, and cardiac function indexes such as BNP and hs-cTnT were measured. The differences of CRP, PCT, BNP and hs-cTnT levels between the two groups and their relationship with cardiac function in patients with acute left heart failure complicated with pulmonary infection were observed. Diagnostic value of above indicators for patients were explored.

  Results  The levels of CRP, PCT, BNP and hs-cTnT in the infected group were the highest, and lowest in the control group(P < 0.05). There were positive correlation between cardiac function grading and serum CRP, PCT, BNP, hs-cTnT levels (r=0.755 8, 0.796 1, 0.921 6, 0.899 5, respectively, P < 0.05). The positive rates of CRP, PCT, PCT, BNP, and hs-cTnT in infected group were significantly higher than those in control group and non-infected group taking CRP≥15 ng/L, PCT≥0.15 ng/mL, BNP≥870 ng/L, hs-cTnT≥8 ng/mL as positive criteria (P < 0.05).

  Conclusion  The levels of serum inflammatory factors such as CRP, PCT and cardiac function indicators such as BNP and hs-cTnT in patients with acute left heart failure can be used as important indicators for the diagnosis of early pulmonary infection, and above indicators can reflect the severity of pulmonary infection, and can be the guidance of treatment pulmonary infection in patients with acute left heart failure.