Effect observation of early application of low molecular weight heparin calcium in prevention of coagulation dysfunction in patients with respiratory failure

ZHANG Sanhong

doi:10.7619/jcmp.201921017

Journal of Clinical Medicine in Practice > 2019 > 23(21): 58-60. > DOI: 10.7619/jcmp.201921017

ZHANG Sanhong. Effect observation of early application of low molecular weight heparin calcium in prevention of coagulation dysfunction in patients with respiratory failure[J]. Journal of Clinical Medicine in Practice, 2019, 23(21): 58-60. DOI: 10.7619/jcmp.201921017

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Effect observation of early application of low molecular weight heparin calcium in prevention of coagulation dysfunction in patients with respiratory failure

ZHANG Sanhong

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Received Date: August 10, 2019
Accepted Date: September 27, 2019
Available Online: February 28, 2021
Published Date: November 14, 2019

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Abstract

Abstract

Objective To explore the effect of early application of low molecular weight heparin calcium on the prevention of coagulation dysfunction in patients with respiratory failure.
Methods A total of 92 patients with respiratory failure were randomly divided into two groups, with 46 cases in each group. The patients in both groups were given regular treatment, such as cough relief, expectoration, asthma relief, mechanical ventilation and low flow oxygen inhalation. On this basis, the study group was given hypodermic injection of low molecular weight heparin calcium. The blood gas analysis indexes before and after treatment were compared between two groups, including pH value, partial pressure of arterial carbon dioxide[p(CO₂)] and partial pressure of arterial blood oxygen[p(O₂)]. The coagulation function including partial thromboplastin time (APTT), prothrombin time (PT), D-Dimer (D-D), platelet (PLT) of the two groups before and after treatment was compared.
Results After treatment, the pH, p(CO₂) and p(O₂) levels of the two groups significantly improved, and the pH, p(CO₂) and p(O₂) levels of the study group were significantly higher than those of the control group (P < 0.05). After treatment, APTT, PT, D-D and PLT in both groups significantly improved when compared with those before treatment, and APTT, PT, D-D and PLT in the study group were significantly better than those in the control group (P < 0.05).
Conclusion Early application of low molecular weight heparin calcium is effective and safe in the treatment of respiratory failure, which can improve the coagulation function and blood gas indexes, reduce the rate of thrombosis, and promote the improvement of disease condition.
- low molecular weight heparin calcium,
- respiratory failure,
- coagulation function,
- D-dimer,
- platelet,
- efficacy

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References (23)

References

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