Objective To investigate the effect of amlodipine versus benazepril in treatment of arteriosclerosis in patients with renal hypertension.
Methods One hundred and seventy-five patients with renal hypertension in our hospital were randomly divided into two groups. Group A(n=94) received amlodipine for 5~10 mg once a day, and group B(n=81) received benazepril for 10~20 mg once a day. Blood pressure and arteriosclerosis indicators including brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI) were measured before and after 8 months of anti-hypertensive therapy.
Results The blood pressure after treatment of both groups significantly decreased compared with before treatment (P < 0.05), while there were no significant between-group differences in blood pressures before and after treatment(P>0.05). After treatment, baPWV of B group was significantly lower, ABI was significantly higher than that before treatment (P < 0.05), but no significant differences were found in abore indicators before and aftertreatment in A groups(P>0.05).
Conclusion Benazepril has better effect in treatment of arteriosclerosis caused by renal hypertension than amlodipine.
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