Effect of amlodipine versus benazepril in treatment of arteriosclerosis in patients with renal hypertension

  Objective  To investigate the effect of amlodipine versus benazepril in treatment of arteriosclerosis in patients with renal hypertension.

  Methods  One hundred and seventy-five patients with renal hypertension in our hospital were randomly divided into two groups. Group A(n=94) received amlodipine for 5~10 mg once a day, and group B(n=81) received benazepril for 10~20 mg once a day. Blood pressure and arteriosclerosis indicators including brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI) were measured before and after 8 months of anti-hypertensive therapy.

  Results  The blood pressure after treatment of both groups significantly decreased compared with before treatment (P < 0.05), while there were no significant between-group differences in blood pressures before and after treatment(P>0.05). After treatment, baPWV of B group was significantly lower, ABI was significantly higher than that before treatment (P < 0.05), but no significant differences were found in abore indicators before and aftertreatment in A groups(P>0.05).

  Conclusion  Benazepril has better effect in treatment of arteriosclerosis caused by renal hypertension than amlodipine.