Association between Helicobacter pylori infection and early renal damage in children with Henoch-Schonlein purpura

  Objective  To investigate the correlation between Helicobacter pylori (Hp) infection and Henoch-Schonlein purpura (HSP) and its influence on early renal damage in children.

  Methods  A total of 151 children with HSP were enrolled, among whom 52 HSP cases complicating with Hp infection were randomly divided into group A and group B, given Hp eradication treatment on the basis of routine treatment, and routine treatment, respectively. Another 99 HSP cases without HP infection treated with routine treatment were selected as C group. The urinary microprotein including urinary β₂ microglobulin (β₂-MG), urinary α₁ microglobulin (α₁-MG), urinary micro transferrin (TRF), urinary albumin (UAlb), urinary immunoglobulin G (UIgG), were examined at the initial diagnosis, 1, 3, and 6 months of the disease course. The examination results of differed courses were compared in three groups.

  Results  Among 151 children with HSP, 52 cases were Hp-positive, with a detection rate of 34.4%. In terms of early renal dysfunction rate, group B was higher 5 than group C (P < 0.05). At 3 months, the level of α₁-MG in group B was higher than that in group A and C, and the level of UAlb in group B was higher than that in group C, the differences were statistically significant (P < 0.05); at 6 months, the level of β₂-MG in group B was higher than that in group A and C(P < 0.05).

  Conclusion  HSP children with Hp infection are more prone to occur renal damage than those without Hp infection, and Hp eradication therapy can reduce the incidence of renal damage. Early stage of renal damage in children with Henoch-Schonlein purpura mainly involves glomerulus or glomerulus along with tubule. Moreover, α₁-MG and UAlb are sensitive indicators in judging early renal damage in urinary microprotein.