Characteristics of intestinal microflora in patients with chronic obstructive pulmonary disease and its correlation with inflammatory indexes and pulmonary function

ZHANG Junying

doi:10.7619/jcmp.201924016

Journal of Clinical Medicine in Practice > 2019 > 23(24): 51-54. > DOI: 10.7619/jcmp.201924016

ZHANG Junying. Characteristics of intestinal microflora in patients with chronic obstructive pulmonary disease and its correlation with inflammatory indexes and pulmonary function[J]. Journal of Clinical Medicine in Practice, 2019, 23(24): 51-54. DOI: 10.7619/jcmp.201924016

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Characteristics of intestinal microflora in patients with chronic obstructive pulmonary disease and its correlation with inflammatory indexes and pulmonary function

ZHANG Junying

Shangluo Central Hospital, Shangluo, Shaanxi, 726000

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Received Date: October 10, 2019
Accepted Date: November 09, 2019
Available Online: February 28, 2021
Published Date: December 27, 2019

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Abstract

Abstract

Objective To explore the characteristics of intestinal microflora in patients with chronic obstructive pulmonary disease (COPD) and its correlation with inflammatory indexes and pulmonary function.
Methods A total of 104 patients with COPD were selected as observation group, and 80 healthy people were selected as control group. The intestinal microflora was compared between two groups. The serum levels of high sensitive C reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) andinterleukin-6 (IL-6) were compared between two groups. The forced expiratory volume in the first second as a percentage of the expected value (FEV₁%) and the ratio of forced expiratory volume in the first second to forced vital capacity (FEV₁/FVC) were compared between two groups. Correlation between the characteristics of intestinal microflora and inflammatory indexes as well as pulmonary function were analyzed.
Results Compared with the control group, there was no significant change in the type of aerobic bacteria in the observation group, and the number of clostridium in the anaerobic bacteria was significantly higher than that in the control group (P < 0.05). The number of fungi in the observation group was more than that in the control group. The numbers of bifidobacteria and lactobacilli (feces) in the observation group were significantly lower than those in the control group (P < 0.05). The levels of serum hs-CRP, TNF-α and IL-6 in the observation group were significantly higher than those in the control group (P < 0.05). FEV₁/FVC and FEV₁% in the observation group were significantly lower than those in the control group (P < 0.05). Pearson correlation analysis showed that there were significant negative correlations between bifidobacteria and FEV₁/FVC, FEV₁%, hs-CRP, TNF-α, IL-6 (r=-0.524、-0.498、-0.477、-0.512、-0.508, P < 0.05), and lactobacilli was also negatively correlated with FEV₁/FVC, FEV₁%, hs-CRP, TNF-α, IL-6 (r=-0.576、-0.466、-0.442、-0.523、-0.439, P < 0.05).
Conclusion There is a significant negative correlation between intestinal microflora and inflammatory indexes and pulmonary function in COPD patients.
- chronic obstructive pulmonary disease,
- intestinal microecology,
- inflammatory factors,
- lung function

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