GUO Zhengping, ZHANG Hong. Effect of bronchoscopic alveolar lavage on inflammation and blood gas index in children with severe pneumonia[J]. Journal of Clinical Medicine in Practice, 2020, 24(1): 50-53. DOI: 10.7619/jcmp.202001013
Citation: GUO Zhengping, ZHANG Hong. Effect of bronchoscopic alveolar lavage on inflammation and blood gas index in children with severe pneumonia[J]. Journal of Clinical Medicine in Practice, 2020, 24(1): 50-53. DOI: 10.7619/jcmp.202001013

Effect of bronchoscopic alveolar lavage on inflammation and blood gas index in children with severe pneumonia

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  • Received Date: October 07, 2019
  • Available Online: December 22, 2020
  • Published Date: August 06, 2020
  • Objective To investigate the effect of bronchoscopic alveolar lavage on inflammatory response and blood gas index in children with severe pneumonia. Methods A total of 94 children with severe pneumonia in our hospital were randomly divided into control group and observation group, with 47 cases in each group. The control group was given routine symptomatic treatment, such as anti-infection, atomized inhalation therapy, and back-patting sputum expectoration, antispasmodic, antipyretic treatments and correction of water electrolyte disorder. The observation group was given bronchoscopic alveolar lavage on the basis of the control group, the treatment was lasted for 7 days. The changes of serum C reactive protein(CRP), procalcitonin(PCT), tumor necrosis factor-α(TNF-α), arterial oxygen partial pressure [p(O2)], arterial oxygen saturation(SaO2), arterial carbon dioxide partial pressure[p(CO2)], acute physiology and chronic health status Ⅱ(APACHE-Ⅱ)scores before and after treatment were observed,and the clinical effects of the two groups were evaluated. Results After treatment, the levels of serum CRP, PCT and TNF-α in the two groups were significantly lower than those before treatment(P< 0.05), and were significantly lower in the observation group than those in the control group(P< 0.05). After treatment, p(O2)and SaO2 in the two groups were significantly higher, and p(CO2)was significantly lower than treatment before(P<0.05), and the observation group changed more significantly compared with the control group(P<0.05). After treatment, APACHEⅡscore in the observation group was significantly lower(P<0.05), and total effective rate was significantly higher than that in the control group - (95.74% vs. 80.85%, P<0.05). Conclusion Bronchoscopic alveolar lavage can effectively reduce the inflammatory reactions and improve the blood gas index level, and improve the clinical effects in children with severe pneumonia.
  • 刘霜, 任晓旭. 儿童重症肺炎合并心力衰竭——争议与实践[J]. 中国小儿急救医学, 2017, 24(3): 166-170.
    梅光日. 抗生素降阶梯治疗小儿重症肺炎疗效观察[J]. 中国妇幼健康研究, 2017, 28(S1): 491-492.
    Deng X J, Yang L P. Effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the SIRS and target organ damage in patients with severe pneumonia complicated by respiratory failure[J]. 海南医科大学学报: 英文版, 2017, 23(14): 9-12.
    代丽, 吴亚斌, 曹欣. 无痛纤维支气管镜术诊治小儿呼吸道疾病的效果观察[J]. 临床肺科杂志, 2018, 23(1): 94-96.
    中华医学会呼吸病学分会. 社区获得性肺炎诊断和治疗指南[J]. 中国实用乡村医生杂志, 2013, 29(2): 651-655.
    于海心, 许敬, 赵翠红, 等. 雾化吸入布地奈德、特布他林结合机械辅助排痰治疗重症肺炎患儿的疗效及护理[J]. 河北医药, 2019, 41(6): 933-936.
    郭晓雅, 张彦卿, 范春艳. 机械通气下小儿重症肺炎的护理[J]. 中日友好医院学报, 2018, 32(5): 316-317.
    石泽亚, 秦月兰, 祝益民, 等. 纤维支气管镜肺泡灌洗联合振动排痰治疗重症肺炎机械通气患者的效果观察: 一项286例患者前瞻性随机对照研究[J]. 中华危重病急救医学, 2017, 29(1): 66-70.
    索风涛, 江李莉, 万娇, 等. 316例重症肺炎患儿细菌病原及耐药性分析[J]. 临床儿科杂志, 2019, 37(2): 86-88

    , 92.
    Calabrese D R, Chong T, Wang A, et al. NKG2C natural killer cells in bronchoalveolar lavage are associated with cytomegalovirus viremia and poor outcomes in lung allograft recipients[J]. Transplantation, 2019, 103(3): 493-501.
    Bhaskaran A, Kabbani D, Singer L G, et al.(1, 3)β-D-glucan in bronchoalveolar lavage of lung transplant recipients for the diagnosis of invasive pulmonary aspergillosis[J]. Med Mycol, 2017, 55(2): 173-179.
    Wang K, Gao M, Yang M Y, et al. Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency[J]. Hum Genomics, 2017, 11: 4-10.
    袁远宏, 张慧, 张新萍, 等. 纤维支气管镜肺泡灌洗对重症肺炎机械通气患儿疗效观察[J]. 中国小儿急救医学, 2019, 26(1): 27-31.
    刘波, 陈栏心. 纤维支气管镜下支气管肺泡灌洗联合局部注药治疗重症肺炎的Meta分析[J]. 广西医学, 2018, 40(3): 314-318.
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