Effects of magnesium sulfate monotherapy and its combination with labetalol on hemorheological parameters in patients with pregnancy-induced hypertension

Objective To observe the effects of magnesium sulfate monotherapy and its combination with labetalol on hemodynamics, hemorheology and pregnancy outcomes in patients with pregnancy-induced hypertension. Methods A totalof 126 patients with pregnancy-induced hypertension were divided into observation group and control group according to the random number table method, with 63 cases in each group. Control group was given monotherapy of magnesium sulfate, and observation group was given magnesium sulfate and its combination with labetalol. The hemodynamics, uterine artery blood flow parameters ［arterial pulsatility index(PI), ratio of arterial systolic pressure to end-diastolic peak blood flow velocity(S/D), arterial blood flow resistance index(RI)］, hemorheology(whole blood reduction viscosity, plasma viscosity, hematocrit, fibrinogen)and antioxidant capacity ［malondialdehyde(MDA), glutathione peroxidase(GSH-Px), superoxide dismutase(SOD)］ before and after treatment were compared between thetwo groups, and the occurrence of adverse drug reactions and adverse pregnancy outcomes were observed in the two groups. Results After treatment, the 24 h mean systolic blood pressure, 24 h mean diastolic blood pressure, 24 h mean arterial pressure, PI, S/D, RI, whole blood reduction viscosity, plasma viscosity, hematocrit and fibrinogen in observation group were significantly lower than those in control group(P<0.05). The MDA - in observation group was significantly lower than that in control group(P<0.05), while the GSH-Px and SOD were significantly higher than those in control group(P<0.05). There was no statistically significant difference in the total incidence of adverse drug reactions between the two groups(P>0.05). The total incidence rate of adverse pregnancy outcomes in observation group was significantly lower than that in control group(33.33%vs. 60.32%, P<0.05). Conclusion Magnesium sulfate combined with labetalol for treatment of pregnancy-induced hypertension can effectively improve blood pressure and uterine artery blood flow, reduce blood viscosity and improve antioxidant capacity, and reduce adverse pregnancy outcomes.