Advance Search
CHANG Binglin, ZHANG Hao. Effect of propofol combined with oxycodone on inflammatory reactions and stress reactions in patients with acute craniocerebral injury[J]. Journal of Clinical Medicine in Practice, 2021, 25(2): 25-27,31. DOI: 10.7619/jcmp.20200572
Citation: CHANG Binglin, ZHANG Hao. Effect of propofol combined with oxycodone on inflammatory reactions and stress reactions in patients with acute craniocerebral injury[J]. Journal of Clinical Medicine in Practice, 2021, 25(2): 25-27,31. DOI: 10.7619/jcmp.20200572
shu

Effect of propofol combined with oxycodone on inflammatory reactions and stress reactions in patients with acute craniocerebral injury

  • Department of Neurosurgery, Anyang District Hospital in Puyang City of Henan Province, Anyang, Henan, 455000

More Information
  • Received Date: August 19, 2020
  • Available Online: January 26, 2021
  • Published Date: January 27, 2021
    Graphical Abstract
    • Abstract
  •   Objective  To investigate the effect of propofol combined with oxycodone on inflammatory reactions and stress reactions in patients with acute craniocerebral injury.
      Methods  Totally 95 patients with acute craniocerebral injury were randomly divided into control group (n=47, treated by propofol and remifentanil for anesthesia) and observation group (n=48, treated by propofol and oxycodone hydrochloride for anesthesia). The anesthetic effect, analgesic effect, oxidative stress reactions of brain tissues and adverse reactions were compared between the two groups.
      Results  The postoperative recovery time of anesthesia, extubation time, eye-opening time, mean arterial pressure (MAP) and heart rate (HR) of the observation group were significantly shorter or lower than those of the control group (P < 0.05). The VAS scores of the observation group at 1 hour, 6, 12 and 24 hours after operation were significantly lower than those of the control group (P < 0.05). The levels of myelin basic protein (MBP), neuron specific enolase (NSE), S-100B protein and D-dimer (D-D) in the observation group were significantly lower than those in the control group during operation and 24 hours after operation (P < 0.05). The incidence of adverse reactions in the observation group was 10.42%, which was significantly lower than 27.66% in the control group (P < 0.05).
      Conclusion  Propofol combined with oxycodone can reduce the oxidative stress degree of brain tissue in patients with acute craniocerebral injury, improve the effects of anesthesia and analgesia, and cause less adverse reactions.
    • FullText(HTML)
    • References (8)
  • [1]
    田源, 蒋烨. 急性颅脑损伤的临床救治与分析[J]. 临床医药文献电子杂志, 2019, 6(60): 70-71. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWX201960047.htm
    [2]
    冯冠军. 瑞芬太尼联合丙泊酚对颅脑损伤患者的麻醉效果及对术中血流动力学的影响[J]. 河南医学研究, 2020, 29(11): 2037-2038. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYX202011052.htm
    [3]
    周斌, 陈文迪. 丙泊酚联合羟考酮对急性颅脑损伤患者的治疗效果及对炎性反应、应激反应的影响[J]. 浙江创伤外科, 2020, 25(1): 163-165. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJCW202001085.htm
    [4]
    中国医师协会神经外科医师分会. 中国颅脑创伤外科手术指南[J]. 中华神经外科杂志, 2009, 25(2): 100-101. https://www.cnki.com.cn/Article/CJFDTOTAL-SJCW201501028.htm
    [5]
    符玲玲. 羟考酮复合丙泊酚在宫腔镜手术中的麻醉效果[J]. 临床合理用药杂志, 2020, 13(3): 115-116. https://www.cnki.com.cn/Article/CJFDTOTAL-PLHY202003054.htm
    [6]
    朱虹, 陈继超, 房杨, 等. 羟考酮联合丙泊酚用于宫腔镜手术镇痛的临床效果[J]. 中国民康医学, 2018, 30(2): 10-11. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMYX201802005.htm
    [7]
    刘颖, 朱丽洁, 张中军. 羟考酮术后镇痛的研究进展[J]. 医学综述, 2020, 26(9): 1819-1822, 1827. https://www.cnki.com.cn/Article/CJFDTOTAL-YXZS202009029.htm
    [8]
    李岩. 探讨丙泊酚联合盐酸羟考酮在颅脑创伤急诊手术中的麻醉镇痛效果[J]. 黑龙江中医药, 2020, 49(1): 94-95. https://www.cnki.com.cn/Article/CJFDTOTAL-HLZY202001065.htm
    • Related Articles

  • Cited by

    Periodical cited type(5)

    1. 刘晨，叶健文，王雪梅，李桦. 血清中微小RNA-506、微小RNA-934水平对胰腺癌患者术后生存结局的预测价值. 实用临床医药杂志. 2024(05): 40-43 . 本站查看
    2. 谢扬帆，曹玲敏，汪雪媛，林川，黄海溶. 中国胰腺癌患者肠道菌群多样性组成谱的系统评价. 中国循证医学杂志. 2023(02): 186-190 .
    3. 姚钧天，刘亮，郭津生. 胰腺癌的诊断与精准治疗. 西南医科大学学报. 2023(02): 110-115 .
    4. 丛鹏，苏祥杰，李永. 微小RNA-433-3p靶向滑蛋白调控胰腺癌PANC-1细胞恶性生物学行为的研究. 实用临床医药杂志. 2023(14): 19-25 . 本站查看
    5. 高春，江晶晶，冯富娟，甄英丽，张久聪，蒋觐阳. 基于CiteSpace的胰腺癌免疫治疗研究热点的可视化分析. 胃肠病学和肝病学杂志. 2023(11): 1262-1270 .

    Other cited types(2)

Catalog

    Get Citation
    PDF
    XML
    Article views (289) PDF downloads (20) Cited by(7)
    Turn off MathJax
    Article Contents
    Abstract
    References

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return