Correlation between serum matrix metalloproteinase-13 expression levels and lung metastasis in patients with differentiated thyroid carcinoma

ZHOU Shuwei; SU Beibei; FENG Yueqing; JIANG Dongbao; XIAO Xuezhen

doi:10.7619/jcmp.20200593

Journal of Clinical Medicine in Practice > 2021 > 25(1): 77-80. > DOI: 10.7619/jcmp.20200593

ZHOU Shuwei, SU Beibei, FENG Yueqing, JIANG Dongbao, XIAO Xuezhen. Correlation between serum matrix metalloproteinase-13 expression levels and lung metastasis in patients with differentiated thyroid carcinoma[J]. Journal of Clinical Medicine in Practice, 2021, 25(1): 77-80. DOI: 10.7619/jcmp.20200593

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Correlation between serum matrix metalloproteinase-13 expression levels and lung metastasis in patients with differentiated thyroid carcinoma

1.
Department of Head, Neck and Breast Surgery, Xinxiang, Henan, 453000
2.
Department of Dermatology, Xinxiang City Central Hospital in Henan Province, Xinxiang, Henan, 453000

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Received Date: August 21, 2020
Available Online: January 17, 2021
Published Date: January 14, 2021

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Abstract

Abstract

Objective To investigate the expression level of serum matrix metalloproteinase-13 (MMP-13) in patients with differentiated thyroid carcinoma (DTC) and its correlation with lung metastasis.
Methods A total of 70 DTC patients without lung metastasis were included in non-metastatic group, 46 DTC patients with lung metastasis were included in metastatic group, and 35 healthy subjects were included in control group. The changes of expression levels of MMP-13 in serum of three groups were detected and compared. Receiver operating characteristic (ROC) curve was drawn and the clinical diagnostic efficacy of serum MMP-13 was analyzed.
Results The expression levels of MMP-13 in the non-metastatic group and the metastatic group were significantly higher than those in the control group, and the expression level of MMP-13 in the metastatic group was significantly higher than that in the non-metastatic group (P < 0.01). Thyroid capsule invasion (OR=3.449), cervical lymph node metastasis (OR=6.501), mediastinal lymph node metastasis (OR=3.145) and MMP-13 levels (OR=4.369) were all independent risk factors for lung metastasis in patients with DTC. ROC curve results showed that the area under the curve (AUC) of serum MMP-13 expression levels in the diagnosis of lung metastasis in patients with DTC was 0.834 (95%CI, 0.743 to 0.924, P < 0.05). When the cut-off value was 142.58 pg/mL, the diagnostic sensitivity and specificity were 92.14% and 86.39%, respectively.
Conclusion The expression levels of MMP-13 in the serum of DTC patients is significantly increased, and MMP-13 can be used as a serological marker for the diagnosis of lung metastasis.
- differentiated thyroid carcinoma,
- matrix metalloproteinase-13,
- influencing factors,
- clinical diagnostic efficacy,
- markers

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