CHENG Baoxiang, CAO Lei. Expression characteristics of serum homocysteine and hypersensitive C reactive protein in patients with coronary atherosclerotic heart disease and clinical significance[J]. Journal of Clinical Medicine in Practice, 2020, 24(6): 94-97. DOI: 10.7619/jcmp.202006026
Citation: CHENG Baoxiang, CAO Lei. Expression characteristics of serum homocysteine and hypersensitive C reactive protein in patients with coronary atherosclerotic heart disease and clinical significance[J]. Journal of Clinical Medicine in Practice, 2020, 24(6): 94-97. DOI: 10.7619/jcmp.202006026

Expression characteristics of serum homocysteine and hypersensitive C reactive protein in patients with coronary atherosclerotic heart disease and clinical significance

More Information
  • Received Date: January 06, 2020
  • Objective To investigate the expression characteristics and clinical significance of homocysteine(Hcy)and hypersensitive C reactive protein(hs-CRP)in serum of patients with coronary atherosclerotic heart disease(CHD). Methods A total of 105 patients who were hospitalized in the Department of Cardiology of Poyang Donghu Hospital were selected as study subjects, and were selected as CHD group. According to the different types of CHD, the patients were divided into three groups: stable angina pectoris(SAP)group(n=42), unstable angina pectoris(UAP)group(n=36)and acute myocardial infarction(AMI)group(n=27). According to the degree of coronary stenosis, CHD patients were divided into moderate group(n=67)and severe group(n=38). In addition, 30 healthy volunteers for physical examination in the same period were selected as the healthy group. The serum Hcy and hs-CRP levels of healthy group and different subgroups of CHD were measured and compared. The correlations among Hcy, hs-CRP and the degree of coronary stenosis in CHD patients were analyzed by Pearson analysis. Results The levels of Hcy and hs-CRP in SAP group, UAP group and AMI group were significantly higher than those in healthy group(P<0.05). The level of Hcy was gradually increased in SAP group, UAP group and AMI group(P<0.05). The - level of hs-CRP in AMI group was significantly higher than that in SAP group and UAP group(P<0.05). The serum Hcy and hs-CRP levelsin moderate and severe CHD groups were significantly higher than those in healthy group(P<0.05), and the severe group was significantly higher than moderate group(P<0.05). Pearson analysis showed that Hcy was positively correlated with hs-CRP in CHD patients(r= 0.547, P< 0.05), There was a positive correlation between Hcy, hs-CRP and the degree of coronary stenosis(r=0.705, 0.438, P<0.05). Conclusion Serum Hcy and hs-CRP levels are closely related to occurrence of CHD and positively related to the degree of coronary stenosis. The detection of Hcy and hs-CRP in serum is of great value to the diagnosis and risk prediction of CHD.
  • 王德征, 张辉, 徐忠良, 等. 天津市居民1999—2013年冠心病死亡率变化趋势分析[J]. 中华预防医学杂志, 2017, 51(2): 176-179.
    高淑娟, 柯春锦, 姚艳敏, 等. 血清同型半胱氨酸、超敏C反应蛋白和超敏肌钙蛋白I在急性心肌梗死的水平变化和意义[J]. 中国综合临床, 2017, 33(8): 694-697.
    江中林, 彭小敏, 王小群, 等. 不同严重程度冠状动脉疾病患者hs-CRP、VN、MDA和Hcy水平比较分析[J]. 检验医学与临床, 2019, 16(12): 1718-1720.
    宋艳东, 陶英, 王苏, 等. 冠心病患者同型半胱氨酸、血尿酸水平与冠脉病变的相关性[J]. 中华急诊医学杂志, 2017, 26(4): 430-433.
    王志强, 李彩娟, 皇巧苗. 参芍胶囊联合阿托伐他汀治疗冠心病不稳定型心绞痛的疗效及对血清Hcy、hs-CRP、NT-proBNP的影响[J]. 中西医结合心脑血管病杂志, 2018, 16(6): 734-737.
    周函, 徐健, 黄文胜, 等. 稳定型心绞痛和不稳定型心绞痛与同型半胱氨酸水平的相关性[J]. 中国老年学杂志, 2016, 36(9): 2099-2101.
    梁灵, 王名南, 周萍. 血清同型半胱氨酸在不同类型冠状动脉粥样硬化性心脏病中的表达及与冠状动脉病变程度的关系[J]. 实用医技杂志, 2019, 26(5): 566-567.
    钟巧妮, 黄变昌. 冠心病患者血清HCY、hs-CRP和NT-proBNP检测的临床意义[J]. 中西医结合心血管病电子杂志, 2018, 6(13): 80-81.
    江中林, 彭小敏, 王小群, 等. 不同严重程度冠状动脉疾病患者hs-CRP、VN、MDA和Hcy水平比较分析[J]. 检验医学与临床, 2019, 16(12): 1718-1720.
    张秋焕, 辛成德, 钟白云. 同型半胱氨酸和超敏C反应蛋白与冠状动脉粥样硬化性心脏病的相关性分析[J]. 中国现代医学杂志, 2017, 27(28): 66-69.
    邹云法, 余文华, 徐丽君, 等. NO、ET-1、Hcy联合检测在冠心病中的诊断价值[J]. 中华全科医学, 2019, 17(7): 1178-1180.
    祁景蕊, 赵殿儒, 王玉. 老年急性冠脉综合征病人血管内皮功能与Lp-PLA2、Hcy水平的相关性研究[J]. 中西医结合心脑血管病杂志, 2019, 17(14): 2162-2165.
    史威力, 赵尊兰, 赵英帅, 等. 盾叶冠心宁对冠心病患者同型半胱氨酸、血脂和内皮功能的影响[J]. 中国心血管病研究, 2018, 16(1): 68-73.
    Li Z Q, Xie C Y, Wang Y. Changes and significance of serum inflammatory factors, UA, Hcy and small dense low-density lipoprotein levels in patients with coronary heart disease[J]. 海南医科大学学报: 英文版, 2017, 23(19): 7-10.
    李小林, 程伟宁, 黄龙虎, 等. 冠心病患者血清脂肪因子与超敏C反应蛋白水平变化及临床意义[J]. 中国心血管病研究, 2019(3): 223-226.
    刘占伟. 血栓通联合阿司匹林对冠心病患者介入术后血清超敏C反应蛋白、血管内皮生长因子水平的影响[J]. 实用临床医药杂志, 2017, 21(11): 151-153.
    沈正, 刘兴德, 韦波, 等. 血清超敏C反应蛋白对冠状动脉粥样硬化性心脏病PCI手术患者危险分层与评估预后的价值[J]. 重庆医学, 2018, 47(1): 54-56.
    黄纪卫, 蒋毅, 肖勇强, 等. 血清hs-CRP、TNF-α及VEGF水平对冠心病严重程度的预测价值[J]. 疑难病杂志, 2017, 16(12): 1205-1208.
  • Related Articles

    [1]WU Mei, WANG Sisi. Influencing factors of lactational insufficiency at 72 hours postpartum and construction of nomogram model[J]. Journal of Clinical Medicine in Practice, 2024, 28(4): 61-65, 69. DOI: 10.7619/jcmp.20233011
    [2]GUO Zhimin. Effect of nursing intervention on lactation and postpartum depression of puerperas with cesarean section[J]. Journal of Clinical Medicine in Practice, 2020, 24(9): 120-123. DOI: 10.7619/jcmp.202009035
    [3]TU Lei, LYU Meng, WANG Yuxiao, CHEN Jie, XU Hui. Effect of Wangbu Liuxing seed ear acupuncture intervention on maternal milk secretion after natural birth[J]. Journal of Clinical Medicine in Practice, 2018, (20): 136-138. DOI: 10.7619/jcmp.201820042
    [4]WANG Jun. Effect of early lactation initiation and individualized guidance on breastfeeding of primiparae[J]. Journal of Clinical Medicine in Practice, 2018, (10): 61-64. DOI: 10.7619/jcmp.201810018
    [5]MEI Jihui. Effect of fast track surgery on deep venous thrombosis in pregnant women undergoing cesarean section[J]. Journal of Clinical Medicine in Practice, 2018, (6): 97-99,103. DOI: 10.7619/jcmp.201806028
    [6]GONG Zhuo, MA Cailian, LI Xiaomei. Effect of fined nursing model on the rehabilitation and nursing quality in cesarean section puerperae[J]. Journal of Clinical Medicine in Practice, 2017, (10): 115-119. DOI: 10.7619/jcmp.201710035
    [7]LEI Zhiping, DAI Mingyue, XIAO Xuemei, ZHU Deqiao. Application effect of refined nursing for cesarean section patients simultaneously operated myomectomy[J]. Journal of Clinical Medicine in Practice, 2017, (2): 111-113. DOI: 10.7619/jcmp.201702035
    [8]BAI Xiaowei. Clinical characteristics of neuromyelitis optica patients combined with syndrome of inappropriate antidiuretic hormone secretion and its nursing[J]. Journal of Clinical Medicine in Practice, 2016, (22): 33-35. DOI: 10.7619/jcmp.201622011
    [9]LIU Linan, WANG Suli, LI Jinghua, CHENG Chen. Effect of short-term dietary restriction on gastrointestinal hormone and fat-secreted hormone in patients with metabolic syndrome[J]. Journal of Clinical Medicine in Practice, 2016, (3): 56-58. DOI: 10.7619/jcmp.201603017

Catalog

    Article views (376) PDF downloads (8) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return