Effect of nifedipine combined with magnesium sulfate on pregnancy induced hypertension and cardiac as well as renal function in pregnant women

Objective To investigate the effect of nifedipine combined with magnesium sulfate in the treatment of pregnancy induced hypertension, and to observe its impact on cardiac and renal function. Methods A total of 78 pregnant women with hypertension during pregnancy were randomly divided into control group(n=39)and observation group(n=39), and all pregnant women were given sedation, diuresis and other basic treatments. The control group was given magnesium sulfate intravenous drip treatment, while the observation group was additionally given oral administration of nifedipine on the basis of the control group. Systolic blood pressure(SBP)and diastolic blood pressure(DBP)were measured before and after treatment, and the clinical effect was evaluated. At the same time, the changes of left ventricular ejection fraction(LVEF), urea nitrogen(BUN)and creatinine(SCr)were measured before and after treatment. Results The levels of SBP and DBP in the two groups were significantly lower than those treatment before(P<0.05), and was lower in the observation group than the control group(P<0.05). The total effective rate of the observation group was 97.44%, which was higher than 79.49% in the control group(P<0.05). There was no significant difference in LVEF before and after treatment in the control group(P>0.05), while levels of BUN and SCr were decreased(P<0.05). The observation group had significant increase in LVEF, and significant decrease in BUN, SCr after treatment(P<0.05). The heart and kidney function indicators above in the observation group were better than that in the control group(P<0.05). Conclusion Nifedipine combined with magnesium sulfate can effectively relieve the symptoms and signs of pregnant women with pregnancy induced hypertension, increase the clinical efficacy, and improve the - heart and kidney function. It is of great significance to protect the health of mother and fetus and improve the pregnancy outcomes.