Application of dexmedetomidine for children undergoing fiberbronchoscope and bronchoalveolar lavage

  Objective  To investigate the effect of dexmedetomidine for children undergoing fiberbronchoscope and bronchoalveolar lavage.

  Methods  A total of 54 children undergoing fiberbronchoscopy and a bronchoalveolar lavage were randomly divided into dexmedetomidine group (Dex group) and control group, with 27cases in each group. Both groups were given general anesthesia, Dex group was given dexmedetomidine before surgery, and control group was given normal saline according to the same method. The vital signs were observed and the levels of tumor necrosis factor-α (TNF-α), total protein and interleukin-1β (IL-1β) were compared in the two groups.

  Results  The serum TNF-α and total protein levels in the Dex group were significantly lower than those in the control group (P< 0.05). The TNF-α and IL-1β levels in bronchoalveolar lavage fluid (BALF) in the Dex group were significantly lower than those in the control group (P< 0.05).

  Conclusion  Dexmedetomidine can reduce lung inflammation and plays a protective role in the lungs of children undergoing fiberbronchoscopic examination and bronchoalveolar lavage.