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GUO Jian, TANG Jin, ZHU Liang, QIAN Fenghua, ZHAO Lei, QIAN Yiming. Study on relationships between traditional Chinese medicine syndromes and oxygenation index, lactic acid, D-dimer in patients with severe pneumonia[J]. Journal of Clinical Medicine in Practice, 2021, 25(1): 81-84. DOI: 10.7619/jcmp.20200734
Citation: GUO Jian, TANG Jin, ZHU Liang, QIAN Fenghua, ZHAO Lei, QIAN Yiming. Study on relationships between traditional Chinese medicine syndromes and oxygenation index, lactic acid, D-dimer in patients with severe pneumonia[J]. Journal of Clinical Medicine in Practice, 2021, 25(1): 81-84. DOI: 10.7619/jcmp.20200734
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Study on relationships between traditional Chinese medicine syndromes and oxygenation index, lactic acid, D-dimer in patients with severe pneumonia

  • Yueyang Hospital of Integrated Chinese and Western Medicine Affiliated to Shanghai University of Integrated Traditional Chinese and Western Medicine, Shanghai, 200437

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  • Received Date: November 18, 2020
  • Available Online: January 17, 2021
  • Published Date: January 14, 2021
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    • Abstract
  •   Objective  To study relationships between traditional Chinese medicine (TCM) syndromes and oxygenation index[pa(O2)/FiO2], lactic acid (Lac), D-dimer (D-D) in patients with severe pneumonia.
      Methods  A total of 118 patients with severe pneumonia were selected as study objects, and their distribution characteristics of TCM syndromes were observed. APACHE Ⅱscores, blood routine examination, levels of C-reactive protein (CRP), pa(O2)/FiO2, Lac, D-D, serum total bilirubin (TBil) and serum creatinine (Cr) were measured.
      Results  Out of 118 patients with severe pneumonia, there were 68 cases(57.63%) with phlegm-heat accumulating in lungs syndrome, 25 cases (21.19%) with phlegm-dampness obstructing lungs syndrome, 14 cases (11.86%) with heat closure pericardium syndrome, and 11 cases (9.32%) with interior invasion of pathogen and vital qi collapse syndrome. The APACHE Ⅱ scores, the levels of white blood cell count(WBC), CRP, D-D and TBil in the patients with interior invasion of pathogen and vital qi collapse syndrome and heat closure pericardium syndrome were significantly higher, and the levels of pa(O2)/FiO2 were significantly lower than those with phlegm-dampness obstructing lungs syndrome and phlegm-heat accumulating in lungs syndrome (P < 0.05). The levels of Lac and Cr in patients with interior invasion of pathogen and vital qi collapse syndrome were higher than those with other syndromes(P < 0.05). The levels of WBC and CRP in patients with phlegm-heat accumulating in lungs syndrome were significantly higher than those with phlegm-dampness obstructing lungs syndrome (P < 0.05); the levels of D-D in patients with interior invasion of pathogen and vital qi collapse syndrome were significantly higher than those with heat closure pericardium syndrome (P < 0.05).
      Conclusion  At admission, TCM syndromes of patients with severe pneumonia mainly include phlegm-heataccumulating in lungs, phlegm-dampness obstructing the lungs, heat closure pericardium, and interior invasion of pathogen and vital qi collapse, and the most commonly occurring syndrome is phlegm-heat accumulating in lungs. The detection of pa(O2)/FiO2, Lac and D-D levels has certain reference value for TCM syndrome differentiation.
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    • References (11)
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