Clinical study of non-invasive high frequency oscillatory ventilation combined with pulmonary surfactant in treatment of neonates with neonatal respiratory distress syndrome

Objective To explore the effect of non-invasive high frequency oscillatory ventilation(NHFOV)combined with pulmonary surfactant(PS)in the treatment of neonates with neonatal respiratory distress syndrome. Methods A total of 60 neonates with neonatal respiratory distress syndrome were selected and randomly divided into control group(n=30)and observation group(n=30). The control group was treated with non-invasive positive pressure ventilation(NIPPV)and PS, while the observation group was treated with NHFOV and PS. The therapeutic effect, mean arterial pressure(MAP), arterial oxygen partial pressure ［p(O₂)］, arterial carbon dioxide partial pressure ［p(CO₂)］, fraction of inspiration O₂(FiO₂), oxygenation index(OI)and complications were compared between the two groups. Results The total effective rate of the observation group was 90.0%, which was significantly higher than 70.0% of the control group(P<0.05). After treatment, the p(O₂)level of the observation group was significantly higher than that of the control group, and the MAP, p(CO₂), FiO₂ and OI levels of the observation group were significantly lower than the control group(P<0.05). There were no significant differences in the incidence rates of pneumonia, pneumothorax and pulmonary hemorrhage between the two groups(P>0.05). Conclusion NHFOV combined with PS shows a significant effect in the treatment of neonates with neonatal respiratory distress syndrome, which can significantly improve the arterial blood gas indexes without increasing the incidence of complications.