Research advance on relationship between tetrahydrobiopterin and tumor

ZHU Caiyun; CHEN Yong

doi:10.7619/jcmp.202008034

Journal of Clinical Medicine in Practice > 2020 > 24(8): 124-127. > DOI: 10.7619/jcmp.202008034

ZHU Caiyun, CHEN Yong. Research advance on relationship between tetrahydrobiopterin and tumor[J]. Journal of Clinical Medicine in Practice, 2020, 24(8): 124-127. DOI: 10.7619/jcmp.202008034

Citation:

ZHU Caiyun, CHEN Yong. Research advance on relationship between tetrahydrobiopterin and tumor[J]. Journal of Clinical Medicine in Practice, 2020, 24(8): 124-127. DOI: 10.7619/jcmp.202008034

Citation:

ZHU Caiyun, CHEN Yong. Research advance on relationship between tetrahydrobiopterin and tumor[J]. Journal of Clinical Medicine in Practice, 2020, 24(8): 124-127. DOI: 10.7619/jcmp.202008034

PDF (847 KB)

Research advance on relationship between tetrahydrobiopterin and tumor

ZHU Caiyun¹,
CHEN Yong^2, ,

1. Yangzhou University, Yangzhou, Jiangsu, 225000;
2. Department of Oncology, School of Clinical Medicine of Yangzhou University, Yangzhou, Jiangsu, 225000

More Information

Received Date: February 04, 2020

Graphical Abstract

Abstract

Abstract

Cancer threatens human's life and its incidence is increasing year by year. The pathogenesis of cancer is complex, and its occurrence is the result of multi-factor interaction and multistage process. With the functions of anti-oxidation and removing active nitrogen oxides, tetrahydrobiopterin(BH4)is a coenzyme of aromatic amino acid hydroxylase and nitric oxide synthase, and plays a key role in a series of physiological and pathological process in vivo. Recent studies has shown that BH4 plays a role in the occurrence and development of malignant tumor, and has double functions in promoting and inhibiting the development of tumor.
- tetrahydrobiopterin,
- malignant tumor,
- molecular mechanism

FullText(HTML)

References (35)

References

Heron M. Deaths: leading causes for 2016[J]. Natl Vital Stat Rep, 2018, 67(6): 1-77.

Al-Shaheri F N, Al-Shami K M, Gamal E H, et al. Association of DNA repair gene polymorphisms with colorectal cancer risk and treatment outcomes[J]. ExpMolPathol, 2020, 113: 104364.

向雨, 郑小鹏, 冯婧, 等. 原发性肝癌患者血清肿瘤标志物与肿瘤组织中凋亡调节基因的表达[J]. 黑龙江医药科学, 2019, 42(4): 4-5

, 12.

Singh S, Hassan D, Aldawsari H M, et al. Immune checkpoint inhibitors: a promising anticancer therapy[J]. Drug Discov Today, 2020, 25(1): 223-229.

Chen L Y, Zeng X, Wang J H, et al. Roles of tetrahydrobiopterin in promoting tumor angiogenesis[J]. AmJPathol, 2010, 177(5): 2671-2680.

Werner E R, Blau N, Thöny B. Tetrahydrobiopterin: biochemistry and pathophysiology[J]. Biochem J, 2011, 438(3): 397-414.

Kaneko Y S, Mori K, Nakashima A, et al. Determination of tetrahydrobiopterin in murine locus coeruleus by HPLC with fluorescence detection[J]. Brain ResBrain Res Protoc, 2001, 8(1): 25-31.

代佑果, 崔进, 甘平, 等. 外源性四氢生物蝶呤改善小鼠颈总动脉内膜损伤的实验研究[J]. 临床心血管病杂志, 2015, 31(8): 883-887.

Scheffer D, Lenfers B, Cronin S, et al. Inhibition of tetrahydrobiopterin production compromises T cell mitochondrial bioenergetics and reduces abdominal pain[J]. Free Radical Biology and Medicine, 2019, 145: S94-S94.

田静朴, 李俭强, 李为民. 四氢生物蝶呤与心血管疾病关系的研究进展[J]. 医学综述, 2015, 21(22): 4061-4064.

姚顺, 吴少虹, 柏勇平, 等. GTP环化水解酶Ⅰ/四氢生物蝶呤通路对高血压内皮祖细胞体外活性和体内再内皮化能力的调节[J]. 中国动脉硬化杂志, 2018, 26(3): 265-272.

张正义, 关晓丽, 卢昌宏, 等. 四氢生物蝶呤对大鼠急性心肌缺血再灌注损伤的保护作用及其机制研究[J]. 现代药物与临床, 2016, 31(6): 752-756.

Chuaiphichai S, McNeill E, Douglas G, et al. Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation[J]. Hypertension, 2014, 64(3): 530-540.

Engineer A, Lim Y J, Lu X R, et al. Sapropterin reduces coronary artery malformation in offspring of pregestational diabetes mice[J]. Nitric Oxide, 2020, 94: 9-18.

Mühl H, Pfeilschifter J. Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells[J]. Kidney Int, 1994, 46(5): 1302-1306.

Mori K, Nakashima A, Nagatsu T, et al. Effect of lipopolysaccharide on the gene expression of the enzymes involved in tetrahydrobiopterin de novo biosynthesis in murine neuroblastoma cell line N1E-115[J]. NeurosciLett, 1997, 238(1/2): 21-24.

王卓飞, 陈锦文, 铁璐, 等. 四氢生物蝶呤的合成及其生物学功能[J]. 生理科学进展, 2015, 46(4): 259-264.

Leiva A, Fuenzalida B, Salsoso R, et al. Tetrahydrobiopterin Role in human umbilical vein endothelial dysfunction in maternal supraphysiological hypercholesterolemia[J]. BBA-Molecular Basis of Disease, 2016, 1862(4): 536-544.

Miclescu A, Gordh T. Nitric oxide and pain: "Something old, something new"[J]. Acta AnaesthesiolScand, 2009, 53(9): 1107-1120.

Stewart C R, Obi N, Epane E C, et al. Effects of diabetes on salivary gland protein expression of tetrahydrobiopterin and nitric oxide synthesis and function[J]. JPeriodontol, 2016, 87(6): 735-741.

Xie L, Hu D, Qin H, et al. In vivo gum Arabic-coated tetrahydrobiopterin protects against myocardial ischemia reperfusion injury by preserving Enos coupling[J]. Life Sci, 2019, 219: 294-302.

Moore B J R, Islam B, Ward S, et al. Repurposing of tranilast for potential neuropathic pain treatment by inhibition of sepiapterin reductase in the BH4pathway[J]. ACS Omega, 2019, 4(7): 11960-11972.

Dikalova A, Aschner J L, Kaplowitz M R, et al. Tetrahydrobiopterin oral therapy recouples Enos and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs[J]. AmJPhysiol Lung CellMolPhysiol, 2016, 311(4): L743-L753.

Dai Y G, Cui J, Gan P, et al. Downregulation of tetrahydrobiopterin inhibits tumor angiogenesis in BALB/c-nu mice with hepatocellular carcinoma[J]. OncolRep, 2016, 36(2): 669-675.

Ziche M, Morbidelli L. Molecular regulation of tumour angiogenesis by nitric oxide[J]. Eur Cytokine Netw, 2009, 20(4): 164-170.

Zhao Q, Zheng K, Ma C M, et al. PTPS facilitates compartmentalized LTBP1 S-nitrosylation and promotes tumor growth under hypoxia[J]. MolCell, 2020, 77(1): 95-107.

李婧, 冯娟, 王宪. 一氧化氮相关的巯基亚硝基化修饰及其对血管功能的调控[C] //庆祝《生理学报》创刊90周年大会论文集. 无锡, 2017: 41-54.

林惠昆, 李翠, 柯学. NO参与的S-亚硝基化反应及其生理意义[J]. 安徽农学通报, 2009, 15(10): 48-50.

李静, 柳斌, 樊均明. TGF-β在足细胞生理功能及病理损伤中的作用[J]. 中国中西医结合肾病杂志, 2011, 12(12): 1120-1122.

Syed V. TGF-βsignaling in cancer[J]. J Cell Biochem, 2016, 117(6): 1279-1287.

Seoane J, Gomis R R. TGF-βfamily signaling in tumor suppression and cancer progression[J]. Cold Spring HarbPerspect Biol, 2017, 9(12): a022277.

Lack J, O'Leary J M, Knott V, et al. Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta[J]. JMolBiol, 2003, 334(2): 281-291.

Drews F, Knöbel S, Moser M, et al. Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability[J]. BiochimBiophysActa, 2008, 1783(1): 34-48.

Cronin S J F, Seehus C, Weidinger A, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer[J]. Nature, 2018, 563(7732): 564-568.

Melo F, Sousa R, SoarelJ, et al. Contribution of Tetrahydrobiopterin(BH4)Throughout Tumor Progression: Positive or Negative Regulator of Melanoma Genesis?[J]. Free Radical Biology and Medicine, 2019, 145(Supl1): S72.

[1]	LU Junwei, ZHU Jingzhe, CHEN Hongru, XIE Jumin. Molecular mechanism of luteolin in treatment of cervical cancer based on network pharmacology and molecular docking technology[J]. Journal of Clinical Medicine in Practice, 2024, 28(16): 26-33. DOI: 10.7619/jcmp.20241525
[2]	YIN Huafang, SHA Sha, CAI Yiling, YU Bo, LIU Jia, HE Jia, SUN Lingdi, WANG Jian. Research progress in the molecular mechanisms and prevention strategies of ovarian injury related to cervical cancer radiotherapy[J]. Journal of Clinical Medicine in Practice, 2024, 28(10): 141-144. DOI: 10.7619/jcmp.20240044
[3]	YANG Hui, XIONG Yuan, CHENG Long, QIAN Ming, JI Li. Mechanism of Dengzhan Shengmai capsule in treating coronary heart disease based on network pharmacology and molecular docking technology[J]. Journal of Clinical Medicine in Practice, 2024, 28(9): 1-8, 14. DOI: 10.7619/jcmp.20240541
[4]	WANG Tengfei, CHEN Qian, ZUO Shi. New development and future prospects of disulfidptosis in malignant tumors[J]. Journal of Clinical Medicine in Practice, 2023, 27(17): 145-148. DOI: 10.7619/jcmp.20232477
[5]	WANG Zhenglin, TANG Jie, CHEN Jiawei, LIU Zixiang, ZHOU Shaobo. The role and significance of tumor necrosis factor-α in malignant tumor[J]. Journal of Clinical Medicine in Practice, 2023, 27(4): 138-143. DOI: 10.7619/jcmp.20223338
[6]	ZHAO Jianfeng, CHEN Kai. Mechanism of Zhizi Dahuang Decoction for anti-liver injury based on network pharmacology[J]. Journal of Clinical Medicine in Practice, 2022, 26(22): 83-89. DOI: 10.7619/jcmp.20223057
[7]	QIN Wei, YIN Zixin, HUA Weiwei, WANG Yujie, WANG Yang, DENG Jialin, CAI Zhaoying, QIAN Yayun. Mechanisms of Marsdenia tenacissima in inhibiting gastric cancer based on network pharmacologyand molecular docking technology[J]. Journal of Clinical Medicine in Practice, 2022, 26(1): 1-7,17. DOI: 10.7619/jcmp.20213297
[8]	GAN Lihua, LI Zhimin, HE Quan, YANG Kun, GUO Chaofeng. Study on the mechanism of herbal pair of Banxia-Huanglian in treatment of gastroesophageal reflux disease based on molecular docking and network pharmacology[J]. Journal of Clinical Medicine in Practice, 2021, 25(21): 1-6. DOI: 10.7619/jcmp.20211655
[9]	WANG Lei, CHEN Kun. Analysis in mechanism of Taohong Siwu Decoction in the treatment of femoral head necrosis based on network pharmacology[J]. Journal of Clinical Medicine in Practice, 2021, 25(2): 10-15,19. DOI: 10.7619/jcmp.20200915
[10]	REN Minshan, HUANG Shanshan, GUO Wenxiu. Effects and mechanisms of erigeron injection in improving the hypercoagulable state of malignant tumors[J]. Journal of Clinical Medicine in Practice, 2013, (14): 62-64. DOI: 10.7619/jcmp.201314021

Cited By

Cited by

Periodical cited type(4)

1.	李楠，段伟利，袁海胜. 3D打印技术辅助后路植骨联合后路椎弓根内固定对脊柱侧弯患者炎症-应激因子、腰椎功能及生存质量的影响. 中国医学工程. 2024(07): 98-102 .
2.	雷龙跃，郑标，吴慕君. 机器人辅助经皮伤椎置钉治疗胸腰椎爆裂骨折. 临床骨科杂志. 2024(04): 466-470 .
3.	谢守宁，刘伟，韩生寿. OLIF联合后路固定术与TLIF术在腰椎退变性椎管狭窄中的疗效. 中国老年学杂志. 2023(03): 554-558 .
4.	李龙文，李政，徐东，汪晓宁，何燕飞. 微创后路减压椎弓根螺钉钉道强化内固定治疗腰椎骨折的临床疗效分析. 实用医院临床杂志. 2022(01): 115-117 .

Other cited types(0)

Get Citation

PDF

XML

Article views (387) PDF downloads (27) Cited by(4)

Turn off MathJax

Article Contents

Abstract

References

Research advance on relationship between tetrahydrobiopterin and tumor

Abstract

References

Related Articles

Cited by

Periodical cited type(4)

Other cited types(0)

Catalog

Research advance on relationship between tetrahydrobiopterin and tumor

Abstract

References

Related Articles

Cited by

Periodical cited type(4)

Other cited types(0)

Catalog

Export File

Citation

Format

Content