Changes of N-terminal pro-brain natriuretic peptide and soluble receptor for advanced glycation endproducts in puerperas with pregnancy-induced hypertension and their correlations with cardiac function

Objective To investigate the changes of N-terminal pro-brain natriuretic peptide(NT-proBNP)and soluble receptor for advanced glycation endproducts(sRAGE)in puerperas with pregnancy-induced hypertension and their correlations with cardiac function. Methods Totally 120 pregnant women with pregnancy-induced hypertension were selected as observation group, and 60 healthy pregnant women were selected as control group. The cases in the observation group were further divided into gestational hypertension group(n=82)and preeclampsia group(n=38). The levels of NT-proBNP and sRAGE at time points of the third trimester and one day before delivery were compared among three groups. cardiac ultrasaund indexes such as ratio of early diastolic peak velocity to late diastolic peak velocity(E/A), ratio of early diastolic peak velocity to peak velocity of mitral annulus root(E/Ea), systolic peak velocity of left ventricular sidewall(Sm), peak left ventricular global torsion angle(Ptw), left ventricular end diastolic diameter(LVDd), left atrial diameter(LAD), - systolic left ventricular posterior wall thickness(LVPWd), posterior wall thickness of intraventricular septum(IVSD)and left ventricular ejection fraction(LVEF)were compared among three groups, and the correlations between NT-proBNP, sRAGE and cardiac ultrasaund indexes were analyzed. Results The levels of NT-proBNP and sRAGE in the preeclampsia group were significantly higher than those in the gestational hypertension group and the control group(P<0.05), and the levels of NT-proBNP and sRAGE in the gestational hypertension group were significantly higher than those in the control group(P<0.05). E/A and Sm in preeclampsia group were significantly lower than those in gestational hypertension group and control group(P<0.05), while E/Ea and Ptw were significantly higher than those in gestational hypertension group and control group(P<0.05). E/A and Sm in gestational hypertension group were significantly lower than those in control group(P<0.05), while E/Ea and Ptw were significantly higher than those in control group(P<0.05). NT-proBNP was positively correlated with E/Ea and Ptw(P<0.05), while sRAGE was positively correlated with E/Ea and Ptw(P<0.05), and negatively correlated with Sm(P<0.05). Conclusion The levels of NT-proBNP and sRAGE are increased in pregnant women with pregnancy-induced hypertension, and the increasing ranges of NT-proBNP and sRAGE are related to the severity of gestational hypertension and cardiac dysfunction.