Efficiency evaluation of norethisterone combined with Bushen Guchong Zhixue Recipe in treatment of patients with dysfunctional uterine bleeding

Objective To explore the therapeutic effect of norethisterone combined with Bushen Guchong Zhixue Recipe in treatment of patients with dysfunctional uterine bleeding. Methods Totally 96 patients with dysfunctional uterine bleeding were randomly divided into two groups, with 48 cases in each group. The control group was treated with norethisterone, and the study group was treated with norethisterone and Bushen Guchong Zhixue Recipe. Levels of estrogen indexes ［estradiol(E₂), follicle stimulating hormone(FSH), luteinizing hormone(LH)］, endometrial thickness, hemoglobin level, clinical efficacy and adverse reactions were compared between the two groups. Results After treatment, E₂, FSH and LH levels in both groups were significantly lower than those before treatment, and the indexes in study group were significantly lower than the control group(P<0.05). After treatment, the hemoglobin levels in both groups were significantly higher than that before treatment, and the hemoglobin level in study group was significantly higher than that in the control group(P<0.05). After treatment, the endometrial thickness in both groups was significantly smaller than that before treatment, and the endometrial thickness in study group was significantly smaller than that in the control group(P<0.05). The total effective rate of TCM symptom improvement in the study group was 95.83%, which was significantly higher than 81.25% in the control group(P<0.05). The incidence of adverse reactions was 6.25% in the study group and 10.42% in the control group, - and there was no significant difference between two groups(P>0.05). Conclusion Norethisterone combined with Bushen Guchong Zhixue Recipe is safe and effective in the treatment of patients with dysfunctional uterine bleeding, which can improve the estrogen level, increase the content of hemoglobin and reduce the endometrial thickness.