LU Tao, ZUO Junli. Effect of roxithromycin combined with N-acetylcysteine in treatment of chronic obstructive pulmonary disease patients complicating with pulmonary interstitial fibrosis[J]. Journal of Clinical Medicine in Practice, 2020, 24(10): 72-76. DOI: 10.7619/jcmp.202010018
Citation: LU Tao, ZUO Junli. Effect of roxithromycin combined with N-acetylcysteine in treatment of chronic obstructive pulmonary disease patients complicating with pulmonary interstitial fibrosis[J]. Journal of Clinical Medicine in Practice, 2020, 24(10): 72-76. DOI: 10.7619/jcmp.202010018

Effect of roxithromycin combined with N-acetylcysteine in treatment of chronic obstructive pulmonary disease patients complicating with pulmonary interstitial fibrosis

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  • Received Date: February 17, 2020
  • Available Online: August 27, 2020
  • Objective To explore effect of roxithromycin combined with N-acetylcysteine in treatment of chronic obstructive pulmonary disease patients complicating with pulmonary interstitial fibrosis(COPD-PIF)and its influence on pulmonary function. Methods A total of 96 COPD-PIF patients with treatment were enrolled, and were divided into two groups according to random number table method, with 48 cases in each group. The control group was treated with roxithromycin, while experimental group was additionally treated with N-acetylcysteine on basis of control group. All of them were continuously treated for 3 months. The efficacy rate of treatment, changes of lung function indexes and serum inflammatory indexes before and after treatment, occurrence of adverse reactions and quality of life scores were compared between the two groups. Results Out of the 96 patients, there were 92 cases accomplished the experiment, including 47 cases in experimental group and 45 cases in control group. There was no significant difference in efficacy rate of treatment between experimental group and control group(93.62% vs. 84.44%, P>0.05). After treatment, ratios of vital capacity(VC), forced expiratory volume in 1 second(FEV1), and carbon monoxide diffusion capacity(DISO)to predicted value in experimental group were significantly higher than those in control group - (P<0.05). After treatment, levels of interleukin-6(IL-6), interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in experimental group were lower than those in control group(P<0.05). There were no significant differences in incidence of adverse reactions and quality of life scores after treatment between the two groups(P>0.05). Conclusion Roxithromycin combined with N-acetylcysteine has significant efficacy in treating COPD-PIF patients, which can effectively improve lung function indexes and serum inflammatory factors, and has no increase in adverse reactions.
  • 张飔雪. 噻托溴铵联合沙美特罗替卡松对重度COPD患者肺功能、氧化应激状态及脂质水平的影响分析[J]. 中国医学前沿杂志: 电子版, 2017, 9(10): 132-136.
    杜俊凤, 任少达, 迟玉敏, 等. 慢性阻塞性肺疾病并发侵袭性肺曲霉菌病的临床特征和危险因素分析[J]. 中国医学前沿杂志: 电子版, 2017, 9(7): 132-135.
    矫翠婷, 邵玉霞. 保肺康汤对COPD合并肺间质纤维化患者血气、肺功能指标与胸部影像学的影响[J]. 四川中医, 2017, 35(11): 77-80.
    张松, 黄茂. 罗红霉素抑制COPD大鼠炎性介质释放对糖皮质激素抵抗的影响[J]. 实用药物与临床, 2018, 21(6): 611-614.
    甘庆, 王进, 曾兴虹. NAC联合NIPV对AECOPD合并Ⅱ型呼吸衰竭患者肺功能、血气参数和血清SOD、sICAM-1、HMGB-1、sTREM-1水平的影响[J]. 中国医学前沿杂志: 电子版, 2019, 11(8): 122-126.
    中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2007年修订版)[J]. 中华内科杂志, 2007, 46(3): 254-261.
    Cella D F, Bonomi A E, Lloyd S R, et al. Reliability and validity of the Functional Assessment of Cancer Therapy-Lung(FACT-L)quality of life instrument[J]. Lung Cancer, 1995, 12(3): 199-220.
    Demeyer H, Louvaris Z, Frei A, et al. Physical activity is increased by a 12-week semiautomated telecoaching programme in patients with COPD: a multicentre randomised controlled trial[J]. Thorax, 2017, 72(5): 415-423.
    杨晶晶, 聂秀红, 魏兵, 等. COPD患者体重差异对人体成分、运动耐力及预后影响的研究[J]. 中国医学前沿杂志: 电子版, 2018, 10(6): 173-178.
    刘晓明, 李芮. 李芮从肾虚血瘀论治慢性阻塞性肺疾病合并肺间质纤维化的经验[J]. 中医药导报, 2017, 23(15): 116-117.
    李军华, 刘春燕, 喻小菊, 等. 肺功能锻炼对慢性阻塞性肺疾病患者肌肉功能及肺通气功能的影响分析[J]. 中国医学前沿杂志: 电子版, 2017, 9(6): 68-73.
    黄有环, 王瑞光, 李志良. 噻托溴铵联合无创机械通气对重度稳定期慢性阻塞性肺疾病患者肺功能及血清炎性因子的影响[J]. 中国医学前沿杂志: 电子版, 2017, 9(6): 74-77.
    邹琴, 王博龙. 长期小剂量罗红霉素对稳定期慢性阻塞性肺疾病疗效作用的Meta分析[J]. 中国抗生素杂志, 2018, 43(10): 156-164.
    孙丹丹, 徐挺挺, 周王锋, 等. 罗红霉素对人支气管上皮细胞糖皮质激素抵抗的作用及其机制[J]. 中华医学杂志, 2017, 97(28): 2215-2219.
    黄玉芳, 石惠. N-乙酰半胱氨酸联合布地奈德/福莫特罗治疗慢性阻塞性肺疾病急性加重的临床效果[J]. 中国医学前沿杂志: 电子版, 2016, 8(8): 68-71.
    陈珊珊, 李华敏, 陈建寿, 等. 大剂量N-乙酰半胱氨酸联合糖皮质激素治疗慢性阻塞性肺疾病并肺间质纤维化的临床疗效[J]. 实用心脑肺血管病杂志, 2017, 25(3): 97-100.
    胡贵芳, 王治国, 樊莉莉. 乙酰半胱氨酸泡滕片辅助治疗稳定期COPD患者心肺功能、气道重塑的影响[J]. 海南医学院学报, 2017, 23(9): 1195-1198

    , 1202.
    付伟, 辛丽云, 陈乾华. 乙酰半胱氨酸溶液雾化吸入对COPD患者免疫功能及肺功能的影响[J]. 实用药物与临床, 2019, 22(6): 597-600.
    刘勇. N-乙酰半胱氨酸对老年慢性阻塞性肺疾病患者免疫功能及细胞因子的影响[J]. 现代中西医结合杂志, 2017, 26(17): 1880-1882.
    王永仓, 孟婷, 孙莹, 等. 小剂量罗红霉素联合N-乙酰半胱氨酸对支气管扩张合并慢性肺源性心脏病疗效观察[J]. 临床肺科杂志, 2017, 22(12): 2315-2318

    , 2320.
    谷志彬, 房莉颖. 无创呼吸机治疗特发性肺间质纤维化合并呼吸衰竭患者的临床效果[J]. 实用临床医药杂志, 2019, 23(5): 63-65.

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