Effect observation of moxifloxacin in treatment of senile patients with acute exacerbation of chronic obstructive pulmonary disease

SHEN Bo; ZHANG Hao; MAO Shuang; WANG Libin; LI Xuewei

doi:10.7619/jcmp.20201006

Journal of Clinical Medicine in Practice > 2021 > 25(1): 54-57. > DOI: 10.7619/jcmp.20201006

SHEN Bo, ZHANG Hao, MAO Shuang, WANG Libin, LI Xuewei. Effect observation of moxifloxacin in treatment of senile patients with acute exacerbation of chronic obstructive pulmonary disease[J]. Journal of Clinical Medicine in Practice, 2021, 25(1): 54-57. DOI: 10.7619/jcmp.20201006

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Effect observation of moxifloxacin in treatment of senile patients with acute exacerbation of chronic obstructive pulmonary disease

1.
The Third Department of Internal Medicine, The People′s Hospital of Shenyang Economic and Technological Development Zone, Shenyang, Liaoning, 110000
2.
Department of Respiratory and Critical Care Medicine, Air Force Hospital of Northern Theater, Shenyang, Liaoning, 110000
3.
Department of Respiratory Medicine, Huanggu Branch of Northeast International Hospital, Shenyang, Liaoning, 110000
4.
Department of Respiratory Medicine, Liaoning Provincial People′s Hospital, Shenyang, Liaoning, 110000

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Received Date: November 12, 2020
Available Online: January 17, 2021
Published Date: January 14, 2021

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Abstract

Abstract

Objective To observe the clinical efficacy of moxifloxacin in the treatment of senile patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
Methods Totally 130 senile patients with AECOPD were randomly divided into study group and control group, with 65 cases in each group. The control group was treated with cefoperazone/sulbactam and routine therapy, while the study group was treated with moxifloxacin and routine therapy. Indexes such as percentage of forced expiratory volume in the first second in predict value (FEV ₁%), maximum ventilation (MVV), ratio of forced expiratory volume in the first second to forced vital capacity (FEV₁/FVC), serum glutathione peroxidase (GPx), superoxide dismutase (SOD), nitric oxide (NO), malondialdehyde (MDA), endothelin (ET-1), soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-8(IL-8), tumor necrosis factor-α (TNF-α), procalcitonin (PCT) and C-reactive protein (CRP) before and after treatment were compared between two groups.
Results After treatment, the levels of FEV₁%, MVV, FEV₁/FVC, SOD, GPx and NO in the study group were significantly higher than those in the control group, while the levels of MDA, ET-1, sICAM-1, IL-8, TNF-α, PCT and CRP were significantly lower than those in the control group (P < 0.05).
Conclusion Moxifloxacin has a better anti-infection efficacy in treating senile patients with AECOPD, which can reduce the inflammatory reaction and vascular endothelial injury, and enhance anti-oxidant function.

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Effect observation of moxifloxacin in treatment of senile patients with acute exacerbation of chronic obstructive pulmonary disease

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