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YUAN Meifang, WEN Xiaobo, LIU Menglan, JI Wei, YANG Yi, ZHAO Biao. Study on dosimetry of radiotherapy between TomoHelical and TomoDirect with simultaneous integrated boost for tumor bed after breast-conserving surgery of left breast cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(1): 6-9. DOI: 10.7619/jcmp.20201120
Citation: YUAN Meifang, WEN Xiaobo, LIU Menglan, JI Wei, YANG Yi, ZHAO Biao. Study on dosimetry of radiotherapy between TomoHelical and TomoDirect with simultaneous integrated boost for tumor bed after breast-conserving surgery of left breast cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(1): 6-9. DOI: 10.7619/jcmp.20201120
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Study on dosimetry of radiotherapy between TomoHelical and TomoDirect with simultaneous integrated boost for tumor bed after breast-conserving surgery of left breast cancer

  • Department of Radiotherapy, The Third Affiliated Hospital of Kunming Medical University, Yunnan Provincial Tumor Hospital, Kunming, Yunnan, 650118

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  • Received Date: October 13, 2020
  • Available Online: January 17, 2021
  • Published Date: January 14, 2021
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    • Abstract
  •   Objective  To explore the dosimetric characteristics of TomoHelical (TH) and TomoDirect (TD) with simultaneous integrated boost for silver clip marked tumor bed after breast-conserving surgery of left breast cancer.
      Methods  Totally 20 patients with breast-conserving surgery of left breast cancer were selected, and TOMO therapeutic planning system was used to design TH plan and TD plan. The dosimetry parameters of the two plans were analyzed.
      Results  In the comparison of planning gross tumor volume (PGTV) between the two plans, the radiation dose to 2% of the target volume (D2), the radiation dose to 98% of the target volume (D98), the radiation dose to 50% of the target volume (D50) and the conformal index (CI) of the TH plan were higher than those of the TD plan, and the significant difference was observed in CI between two plans (P < 0.05). In the comparison of planning tumor volume (PTV) between the two plans, theD98 and CI of the TH plan were significantly higher than those of the TD plan, D50 was significantly lower than that of the TD plan, but D2 of the TD plan was significantly better than that of the TH plan (P < 0.05). The volume of left lung exposed to 5 Gy radiation dose (V5), 10 Gy radiation dose (V10) and 20 Gy radiation dose (V20), V5 and mean radiation dose (Dmean) of right lung, Dmean of right breast, D2 of spinal cord and Dmean of heart in the TD plan were significantly lower than those in the TH plan (P < 0.05).
      Conclusion  Both TH and TD can meet the clinical dosimetry requirements of simultaneous integrated boost for patients with silver clip marked tumor bed after breast-conserving surgery of left breast cancer, and TD is obviously better than TH in the protection of organs at risk. Therefore, it is suggested that TD technology should be the priority choice for patients with cardiopulmonary disease after breast-conserving surgery and heart injury after chemotherapy.
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    • References (21)
  • [1]
    蒙渡, 唐丰文, 刘锐, 等. 早期乳腺癌保乳术后瘤床区同步加量IMRT的剂量学及疗效分析[J]. 西部医学, 2017, 29(5): 622-626. https://www.cnki.com.cn/Article/CJFDTOTAL-XIBU201705007.htm
    [2]
    何亚男, 罗焕丽, 靳富, 等. TomoDirect技术在乳腺癌术后胸壁放疗中的应用[J]. 中国医学物理学杂志, 2017, 34(6): 555-560, 578. https://www.cnki.com.cn/Article/CJFDTOTAL-YXWZ201706004.htm
    [3]
    MARTA G, HANNA S, GADIA R, et al. Treatment with intensity modulated radiation therapy(IMRT)for breast cancer[J]. Rev Assoc Med Bras, 2014, 60(6): 508-513. doi: 10.1590/1806-9282.60.06.005
    [4]
    LIN Y, WANG B Z. Dosimetric absorption of intensity modulated radiotherapy compared with conventional radiotherapy in breast conserving surgery[J]. Oncol Lett, 2015, 9(1): 9-16. doi: 10.3892/ol.2014.2704
    [5]
    袁美芳, 赵彪, 杨毅, 等. 胸中段食管癌静态调强放疗与容积旋转调强放疗的靶区及危及器官的剂量学参数比较[J]. 实用临床医药杂志, 2020, 24(15): 21-24. doi: 10.7619/jcmp.202015006
    [6]
    李益坤, 刘海, 王晓萍, 等. 螺旋断层放疗与常规调强放疗在乳腺癌保乳术后同步推量中的剂量学比较[J]. 临床肿瘤学杂志, 2013, 18(7): 648-651. https://www.cnki.com.cn/Article/CJFDTOTAL-LCZL201307018.htm
    [7]
    张富利, 侯俊, 陈建平, 等. 不同类型多叶准直器对左侧乳腺癌保乳术后容积旋转调强放疗技术剂量分布的影响[J]. 中国医学物理学杂志, 2017, 34(7): 726-730. https://www.cnki.com.cn/Article/CJFDTOTAL-YXWZ201707015.htm
    [8]
    ONAL C, EFE E, GULER O C, et al. Dosimetric Comparison of Sequential Versus Simultaneous-integrated Boost in Early-stage Breast Cancer Patients Treated With Breast-conserving Surgery[J]. In vivo(Athens, Greece), 2019, 33(6): 2181-2189. http://www.researchgate.net/publication/336896682_Dosimetric_Comparison_of_Sequential_Versus_Simultaneous-integrated_Boost_in_Early-stage_Breast_Cancer_Patients_Treated_With_Breast-conserving_Surgery
    [9]
    杨波, 刘志凯, 侯晓荣, 等. 乳腺癌保乳术后螺旋断层治疗技术的剂量学研究[J]. 中华放射肿瘤学杂志, 2013, 22(5): 411-413. https://www.cnki.com.cn/Article/CJFDTOTAL-SGLC201505016.htm
    [10]
    崔芹玲, 孙岩, 钟文, 等. 早期乳腺癌术后螺旋断层放疗与调强放疗剂量学比较的Meta分析[J]. 肿瘤研究与临床, 2016, 28(12): 828-832.
    [11]
    FRANCO P, CATUZZO P, CANTE D, et al. TomoDirect: an efficient means to deliver radiation at static angles with tomotherapy[J]. Tumori, 2011, 97(4): 498-502. doi: 10.1177/030089161109700414
    [12]
    BORCA V C, FRANCO P, CATUZZO P, et al. Does TomoDirect 3DCRT represent a suitable option for post-operative whole breast irradiation A hypothesis-generating pilot study[J]. Radiat Oncol, 2012, 7: 211-219. doi: 10.1186/1748-717X-7-211
    [13]
    FRANCO P, ZEVERINO M, MIGLIACCIO F, et al. Intensity-modulated and hypofractionated simultaneous integrated boost adjuvant breast radiation employing statics Ports of tomotherapy(TomoDirect): a prospective phase Ⅱ trial[J]. J Cancer Res Clin Oncol, 2014, 140(1): 167-177. doi: 10.1007/s00432-013-1560-8
    [14]
    林金勇, 潘建基, 胡彩容, 等. TomoDirect和TomoHelical技术在左侧乳腺癌保乳术后放疗中的剂量学比较[J]. 中华放射医学与防护杂志, 2017, 37(3): 216-221.
    [15]
    沈奕晨, 王为, 张松方, 等. 乳腺癌螺旋断层放射治疗与调强放射治疗的剂量学研究与临床剂量实测比较[J]. 中国医学物理学杂志, 2018, 35(3): 269-274. https://www.cnki.com.cn/Article/CJFDTOTAL-YXWZ201803005.htm
    [16]
    段云龙, 杨涛, 曲宝林, 等. 乳腺癌保乳切线野三维适形, 切线野正向调强及逆向调强放疗的剂量学评估[J]. 中国医学物理学杂志, 2015, 32(6): 841-846. https://www.cnki.com.cn/Article/CJFDTOTAL-YXWZ201506018.htm
    [17]
    FRANCO P, ZEVERINO M, MIGLIACCIO F, et al. Intensity-modulated and hypofractionated simultaneous integrated boost adjuvant breast radiation employing statics ports of tomotherapy(TomoDirect): A prospective phase Ⅱ trial[J]. J Cancer Res Clin Oncol, 2014, 140(1): 167-177. doi: 10.1007/s00432-013-1560-8
    [18]
    陈高翔, 曲宝林, 杜乐辉, 等. 断层径照技术在乳腺癌保乳术后患者放射治疗中的应用[J]. 中国医学装备, 2017, 14(7): 1-5. https://www.cnki.com.cn/Article/CJFDTOTAL-YXZB201707001.htm
    [19]
    JOO C M, HWAN K S, HOON L J, et al. A Dosimetric Comparative Analysis of TomoDirect and Three-Dimensional Conformal Radiotherapy in Early Breast Cancer[J]. Journal of Breast Cancer, 2015, 18(1): 57-62. doi: 10.4048/jbc.2015.18.1.57
    [20]
    SCHUBERT L K, PATEL R R, SENGBUSCH E, et al. Dosimetric comparison of left-sided whole breast irradiation with 3DCRT, forward-planned IMRT, inverse-planned IMRT, helical tomotherapy, and topotherapy[J]. Radiother Oncol, 2011, 100(2): 241-246. doi: 10.1016/j.radonc.2011.01.004
    [21]
    岳丹, 白燕, 李新迪, 等. 早期乳腺癌保乳术后加速部分乳腺调强放疗与全乳腺同步推量调强放疗的剂量学比较[J]. 肿瘤研究与临床, 2020, 32(8): 546-551.
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