ZHANG Mengpa, GAO Fei, DONG Xiao, CAO Daidi, JIN Jiajia, WANG Rui. Efficacy and safety of valaciclovir hydrochloride granules combined with stomatitis spray in the treatment of children with herpetic stomatitis[J]. Journal of Clinical Medicine in Practice, 2020, 24(12): 107-110. DOI: 10.7619/jcmp.202012030
Citation: ZHANG Mengpa, GAO Fei, DONG Xiao, CAO Daidi, JIN Jiajia, WANG Rui. Efficacy and safety of valaciclovir hydrochloride granules combined with stomatitis spray in the treatment of children with herpetic stomatitis[J]. Journal of Clinical Medicine in Practice, 2020, 24(12): 107-110. DOI: 10.7619/jcmp.202012030

Efficacy and safety of valaciclovir hydrochloride granules combined with stomatitis spray in the treatment of children with herpetic stomatitis

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  • Received Date: April 19, 2020
  • Objective To explore the efficacy and safety of valaciclovir hydrochloride granules combined with stomatitis spray in the treatment of children with herpetic stomatitis. Methods A total of 150 children with herpetic stomatitis were selected and divided into control group A(n=50), control group B(n=50)and experimental group(n=50)according to the sealed envelope method. The control group A was treated with valaciclovir hydrochloride granules, the control group B was treaded with stomatitis spray, the experimental group was treated with valaciclovir hydrochloride granules and stomatitis spray, and all the children were treated for 1 week. The therapeutic effect, relief time of clinical symptoms(regression time of herpes, recovery time of body temperature, rehabilitation time), levels of serum inflammatory factors [interleukin-10(IL-10), interleukin-2(IL-2), tumor necrosis factor-α(TNF-α)], quality of life [score of Infant Dermatology Quality of Life Index(IDQOL)] and safety indicators [result of blood test, adverse reactions] were compared among the three groups. Results After treatment, the therapeutic effect in the experimental group was significantly better than that in the control group A and control group B(P<0.05). The regression time of herpes, recovery time of body temperature and rehabilitation time in the experimental group were significantly shorter than those in the control group A and control group B(P<0.05). After treatment, the level of IL-10 - increased significantly in the three groups, while levels of IL-2 and TNF-α decreased significantly (P<0.05), and changes of levels of IL-10, IL-2 and TNF-α in the experimental group were significantly greater than those in the control group A and the control group B(P<0.05). The IDQOL score in the three groups significantly decreased after treatment, and was significantly lower in the experimental group than that in the control group A and the control group B(P<0.05). There was no significant difference in the result of blood test among the three groups, and no obvious adverse reactions were observed. Conclusion Valaciclovir hydrochloride granules combined with stomatitis spray is effective in the treatment of children with herpetic stomatitis, which can shorten the relief time of clinical symptoms, improve the levels of serum inflammatory factors and the quality of life, and has higher safety.
  • 刘赟. 黄氏祛腐散联合蒲地蓝消炎口服液治疗疱疹性口炎疗效观察[J]. 中国中西医结合耳鼻咽喉科杂志, 2013, 21(6): 460-460

    , 465.
    杨毅, 赵建林. 盐酸伐昔洛韦治疗复发性生殖器疱疹的临床疗效观察[J]. 中国性科学, 2015, 24(11): 77-80.
    高跃忠. 口腔炎喷雾剂联合康复新液治疗小儿疱疹性口腔炎效果观察[J]. 中国乡村医药, 2017, 24(6): 48-49.
    丁彧, 郝明玉. 康复新液联合蒲地蓝消炎口服液治疗疱疹性口炎的临床疗效[J]. 临床医学研究与实践, 2016(12): 58-58.
    王海军. 康复新液与口腔炎喷雾剂对小儿疱疹性口腔炎的疗效及其对血清炎症因子水平的影响[J]. 抗感染药学, 2018, 15(3): 455-457.
    樊英, 康淑红. 黄连解毒丸联合利巴韦林治疗小儿疱疹性口炎的临床研究[J]. 现代药物与临床, 2016, 31(12): 1971-1975.
    谭映红, 杨鸯. 盐酸伐昔洛韦联合开喉剑喷雾剂治疗疱疹性口炎的疗效分析[J]. 儿科药学杂志, 2018, 24(3): 32-34.
    曹旭升. 口腔炎喷雾剂佐治小儿疱疹性咽峡炎80例疗效观察[J]. 光明中医, 2016, 31(22): 3301-3303.
    张美霞, 何浙海, 胡义芝. 口腔炎喷雾剂联合康复新液治疗小儿疱疹性口腔炎临床疗效观察[J]. 临床合理用药杂志, 2015, 8(16): 36-37.
    于少华. 口腔炎喷雾剂联合康复新液治疗小儿疱疹性口腔炎的临床效果分析[J]. 中国实用医药, 2018, 13(4): 107-109.
    袁晓军, 李凤, 丁英, 等. 口腔雾化药物吸入联合小儿双金清热口服液治疗疱疹性口炎的临床疗效[J]. 现代生物医学进展, 2016, 16(6): 1098-1100.
    欧海强, 卢晓珊. 口腔炎喷雾剂联合利巴韦林泡腾颗粒治疗儿童疱疹性口炎疗效分析[J]. 青岛医药卫生, 2017, 49(6): 409-411.
    张红艳. 阿昔洛韦片、溶菌酶肠溶片、小儿双金清热口服液联合治疗小儿疱疹性口腔炎疗效观察[J]. 现代中西医结合杂志, 2014, 23(17): 1875-1877.
    姚翠萍, 王佳壮, 王晶, 等. Au@TiO2纳米核壳与HMME结合体的制备及其光动力疗效初探[J]. 光谱学与光谱分析, 2017, 37(12): 3670-3676.
    昝金云. 洁悠神长效喷雾剂治疗鼻咽癌放疗中放射性口腔黏膜炎的疗效观察[J]. 实用临床医药杂志, 2011, 15(12): 11-12.
    赵鹏, 史家波, 姚志剑. 磁共振成像在抑郁症疗效预测中的作用[J]. 中华行为医学与脑科学杂志, 2017(7): 661-665.
    刘静. 口腔念珠菌病、单纯疱疹性口炎与HIV患者相关性的研究[J]. 湖南师范大学学报: 医学版, 2016, 13(4): 62-65.
    段海真, 胡权, 任达福, 等. 水飞蓟宾过敏误诊为疱疹性口炎一例报告[J]. 天津医药, 2018, 46(1): 91-93.
    阿达来提·麻合苏提, 吾日古力·吾买儿, 买尔哈巴·马合木提, 等. 采用干扰素雾化给药法治疗疱疹性口炎的临床分析[J]. 国际病毒学杂志, 2015, 22(z1): 116-117.
    夏蝉, 余坚, 金龙腾, 等. 疱疹性口炎与疱疹性咽峡炎的病原学检测[J]. 中华全科医学, 2016, 14(10): 1719-1722.
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