GUO Lei, LI Yan, LU Lihui, CHANG Ying, WANG Wenpeng, GAO Jizhao. Analysis in causes and risk factors of death in 53 children with acute leukemia[J]. Journal of Clinical Medicine in Practice, 2021, 25(8): 43-45. DOI: 10.7619/jcmp.20201210
Citation: GUO Lei, LI Yan, LU Lihui, CHANG Ying, WANG Wenpeng, GAO Jizhao. Analysis in causes and risk factors of death in 53 children with acute leukemia[J]. Journal of Clinical Medicine in Practice, 2021, 25(8): 43-45. DOI: 10.7619/jcmp.20201210

Analysis in causes and risk factors of death in 53 children with acute leukemia

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  • Received Date: October 22, 2020
  • Available Online: April 29, 2021
  • Published Date: April 27, 2021
  •   Objective  To explore the causes and risk factors of death in children with acute leukemia (AL) in hospital.
      Methods  Totally 53 dead children due to AL were divided into early death group (n=23) and non-early death group (n=30). The mortality, causes of death and risk factors of death were analyzed in both groups.
      Results  Multiple organ dysfunction syndrome (MODS) and infection were the main causes of death in the early death group, while infection and bleeding were the main causes of death in the non-early death group. Bacterial septicemia was the main cause of death in both groups, and Gram-negative bacteria infection was the main cause. Age less than 1 year old, high white blood cell count and high serum lactate dehydrogenase level were the high risk factors of death in children with AL (P < 0.05).
      Conclusion  For the high risk factors of death such as less than 1 year old, high white blood cell count and high serum lactate dehydrogenase level in children with AL, early implementation of active prevention and treatment measures may reduce the mortality of children.
  • [1]
    蔡玉丽, 邹尧, 陈晓娟, 等. 982例儿童急性淋巴细胞白血病流行病学研究[J]. 中国实验血液学杂志, 2020, 28(2): 371-376. https://www.cnki.com.cn/Article/CJFDTOTAL-XYSY202002008.htm
    [2]
    张丽芬, 李莲, 张晓春. DHA和DAE方案用于儿童急性髓系白血病诱导治疗的临床观察[J]. 临床肿瘤学杂志, 2020, 25(7): 625-630. doi: 10.3969/j.issn.1009-0460.2020.07.009
    [3]
    方建培, 陈纯, 金润铭, 等. 儿童急性白血病的诊断和治疗[M]. 北京: 人民卫生出版社, 2008: 144-150.
    [4]
    许凤玲, 管贤敏, 温贤浩, 等. 儿童急性淋巴细胞白血病化疗相关严重不良反应的临床分析[J]. 中国当代儿科杂志, 2020, 22(8): 828-833. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ202008005.htm
    [5]
    曾星. CCLG-ALL2008方案治疗儿童急性淋巴细胞白血病的死亡相关因素分析[D]. 重庆: 重庆医科大学, 2018.
    [6]
    裴瑜馨, 李毓, 黄慧敏, 等. 儿童严重急性高白细胞白血病致死性并发症诊治策略[J]. 广东医学, 2019, 40(23): 3250-3254. https://www.cnki.com.cn/Article/CJFDTOTAL-GAYX201923004.htm
    [7]
    刘炜, 王天有. 儿童血液肿瘤患者肿瘤溶解综合征诊治进展[J]. 中华儿科杂志, 2019, 57(4): 305-308. doi: 10.3760/cma.j.issn.0578-1310.2019.04.017
    [8]
    方希敏, 潘夏蓁, 钱江潮, 等. 儿童急性白血病化疗后感染的临床分析[J]. 中华医院感染学杂志, 2013, 23(5): 1087-1089. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201305062.htm
    [9]
    牛曼曼, 王宁玲, 刘亢亢, 等. 儿童急性白血病合并败血症56例分析[J]. 中国小儿血液与肿瘤杂志, 2014, 19(6): 308-310. doi: 10.3969/j.issn.1673-5323.2014.06.007
    [10]
    闫晨华, 徐婷, 郑晓云, 等. 中国血液病患者中性粒细胞缺乏伴发热的多中心、前瞻性流行病学研究[J]. 中华血液学杂志, 2016, 37(3): 177-182.
    [11]
    NEWELL L F, HOLTAN S G. Placental growth factor: what hematologists need to know[J]. B lood Rev, 2017, 31(1): 57-62. http://www.sciencedirect.com/science/article/pii/S0268960X16300571
    [12]
    应江伟, 杜灵彬, 郑艳泽, 等. 浙江省肿瘤登记地区2000~2009年白血病发病与死亡分析[J]. 中国肿瘤, 2014, 23(7): 538-542. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHLU201407002.htm
    [13]
    李白, 张春蕾, 刘玉峰. 婴儿急性白血病31例临床分析[J]. 国际儿科学杂志, 2019, 46(5): 382-384. doi: 10.3760/cma.j.issn.1673-4408.2019.05.019
    [14]
    胡莎, 贾荟. 急性白血病患儿血清乳酸脱氢酶水平的观察[J]. 现代临床医学, 2017, 43(5): 366-367. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCD201705016.htm
    [15]
    吴文萍, 孔宏伟, 郑晓燕, 等. 急性淋巴细胞白血病患者感染时超敏C-反应蛋白检测的临床意义[J]. 中华医院感染学杂志, 2015, 25(2): 273-275. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201502014.htm
    [16]
    杨希茹, 薛宁, 付蓉, 等. 儿童急性淋巴细胞白血病血清乳酸脱氢酶的临床研究[J]. 现代生物医学进展, 2016, 16(12): 2271-2273. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201612017.htm
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