Correlation between monocyte to high-density lipoprotein cholesterol ratio and carotid artery stenosis in patients with acute cerebral infarction

CHEN Yuchi; LIU Qiang

doi:10.7619/jcmp.20201217

Journal of Clinical Medicine in Practice > 2021 > 25(3): 36-39. > DOI: 10.7619/jcmp.20201217

CHEN Yuchi, LIU Qiang. Correlation between monocyte to high-density lipoprotein cholesterol ratio and carotid artery stenosis in patients with acute cerebral infarction[J]. Journal of Clinical Medicine in Practice, 2021, 25(3): 36-39. DOI: 10.7619/jcmp.20201217

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Correlation between monocyte to high-density lipoprotein cholesterol ratio and carotid artery stenosis in patients with acute cerebral infarction

CHEN Yuchi,
LIU Qiang^,

Department of Neurology, The Third Hospital Affiliated to Jinzhou Medical University, Jinzhou, Liaoning, 121000

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Received Date: December 25, 2020
Available Online: March 03, 2021
Published Date: March 03, 2021

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Abstract

Abstract

Objective To explore the relationship between monocyte to high-density lipoprotein cholesterol ratio(MHR)and carotid artery stenosis(CAS) in patients with acute cerebral infarction(ACI).
Methods A total of 242 ACI patients were selected as study objects, among whom 41 cases without CAS were selected as control group and 201 patients with CAS were selected as stenosis group. According to the ultrasonic results, the stenosis group was further divided into mild stenosis group (n=88), moderate stenosis group (n=61), severe stenosis and occlusion group (n=52). Logistic regression analysis was used to determine the risk factors of CAS in ACI patients, and ROC curve was used to assess the predictive value of MHR in ACI patients with CAS.
Results The MHR of the stenosis group was significantly higher than that of the control group (P < 0.05). The MHR values of the moderate stenosis group, severe stenosis and occlusion group were significantly higher than those of the control group (P < 0.05). Logistic regression analysis showed that MHR was an independent risk factor for CAS in ACI patients. Receiver operating characteristic (ROC) curve results suggested that when the MHR value was 0.535, the maximum predictive value of CAS for ACI patients was the highest, sensitivity was 40.30%, and specificity was 85.40%(P < 0.05).
Conclusion MHR is an independent risk factor, and may be an indicator to predict CAS in ACI patients.
- acute cerebral infarction,
- carotid artery stenosis,
- monocyte,
- high density lipoprotein cholesterol

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[1]	FROSTEGÅRD J. Immunity, atherosclerosis and cardiovascular disease[J]. BMC Med, 2013, 11: 117-117. doi: 10.1186/1741-7015-11-117
[2]	HERRINGTON W, LACEY B, SHERLIKER P, et al. Epidemiology of atherosclerosis and the potential to reduce the global burden of atherothrombotic disease[J]. Circ Res, 2016, 118(4): 535-546. doi: 10.1161/CIRCRESAHA.115.307611
[3]	RAFIEIAN-KOPAEI M, SETORKI M, DOUDI M, et al. Atherosclerosis: process, indicators, risk factors and new hopes[J]. Int J Prev Med, 2014, 5(8): 927-946. http://europepmc.org/articles/pmc4258672/
[4]	CANPOLAT U, ÇETIN E H, CETIN S, et al. Association of monocyte-to-HDL cholesterol ratio with slow coronary flow is linked to systemic inflammation[J]. Clin Appl Thromb Hemost, 2016, 22(5): 476-482. doi: 10.1177/1076029615594002
[5]	TABAS I, LICHTMAN A H. Monocyte-macrophages and T cells in atherosclerosis[J]. Immunity, 2017, 47(4): 621-634. doi: 10.1016/j.immuni.2017.09.008
[6]	OSSOLI A, REMALEY A T, VAISMAN B, et al. Plasma-derived and synthetic high-density lipoprotein inhibit tissue factor in endothelial cells and monocytes[J]. Biochem J, 2016, 473(2): 211-219. doi: 10.1042/BJ20151000
[7]	BARTER P, GENEST J. HDL cholesterol and ASCVD risk stratification: a debate[J]. Atherosclerosis, 2019, 283: 7-12. doi: 10.1016/j.atherosclerosis.2019.01.001
[8]	段运霞, 周荣, 贺杰. 冠心病患者MHR与冠脉狭窄程度的相关性及其临床意义[J]. 心脏杂志, 2019, 31(3): 282-285.
[9]	LI Y, LI S, MA Y, et al. Relationship between non-high-density lipoprotein cholesterol/apolipoprotein A-I and monocyte/high-density lipoprotein cholesterol ratio and coronary heart disease[J]. Coron Artery Dis, 2020, 31(7): 623-627. doi: 10.1097/MCA.0000000000000881
[10]	陈洁霞, 李结华, 唐海沁. 单核细胞与高密度脂蛋白比值和颈动脉粥样硬化斑块稳定性的相关性研究[J]. 中国临床保健杂志, 2017, 20(4): 383-385. doi: 10.3969/J.issn.1672-6790.2017.04.014
[11]	中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2018[J]. 中华神经科杂志, 2018, 51(9): 666-682. doi: 10.3760/cma.j.issn.1006-7876.2018.09.004
[12]	FASSBENDER K, ROSSOL S, KAMMER T, et al. Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease[J]. J Neurol Sci, 1994, 122(2): 135-139. doi: 10.1016/0022-510X(94)90289-5
[13]	HILGENDORF I, SWIRSKI F K, ROBBINS C S. Monocyte fate in atherosclerosis[J]. Arterioscler Thromb Vasc Biol, 2015, 35(2): 272-279. doi: 10.1161/ATVBAHA.114.303565
[14]	FLORENTIN M, LIBEROPOULOS E N, WIERZBICKI A S, et al. Multiple actions of high-density lipoprotein[J]. Curr Opin Cardiol, 2008, 23(4): 370-378. doi: 10.1097/HCO.0b013e3283043806
[15]	HAFIANE A, GENEST J. High density lipoproteins: Measurement techniques and potential biomarkers of cardiovascular risk[J]. BBA Clin, 2015, 3: 175-188. doi: 10.1016/j.bbacli.2015.01.005
[16]	BOLAYIR A, GOKCE S F, CIGDEM B, et al. Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients[J]. Neurol Neurochir Pol, 2018, 52(2): 150-155. doi: 10.1016/j.pjnns.2017.08.011
[17]	李亚, 李曙, 马于林, 等. 单核细胞/高密度脂蛋白胆固醇比值与冠心病关系的探讨[J]. 中国心血管病研究, 2019(12): 1110-1114. doi: 10.3969/j.issn.1672-5301.2019.12.012
[18]	李晓红. 急性脑梗死患者颈动脉狭窄程度与相关载脂蛋白关系的研究[J]. 中华老年心脑血管病杂志, 2012, 14(12): 1278-1278. doi: 10.3969/j.issn.1009-0126.2012.12.014
[19]	郭俊华, 陆小波, 刘彩玲. 颈动脉狭窄程度对急性脑梗死患者神经功能及血浆纤维蛋白原水平的影响研究[J]. 实用心脑肺血管病杂志, 2016(24): 33-36.
[20]	佟家旭, 姜学明, 刘莹莹. 颈动脉狭窄与急性脑梗死患者同型半胱氨酸, 血小板参数及预后的相关性分析[J]. 实用医院临床杂志, 2020, 17(2): 119-122. doi: 10.3969/j.issn.1672-6170.2020.02.036
[21]	张玉, 张小雨, 李晓红, 等. 急性脑梗死患者颈动脉狭窄程度与相关载脂蛋白关系的研究[J]. 中华老年心脑血管病杂志, 2012(12): 1278-1281. doi: 10.3969/j.issn.1009-0126.2012.12.014

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