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SUN Mo, JIANG Zhihua, CHEN Shoutao. Effect of sitagliptin combined with rosiglitazone on glucose and lipid metabolism as well as insulin resistance in patients with type 2 diabetes[J]. Journal of Clinical Medicine in Practice, 2020, 24(14): 31-33. DOI: 10.7619/jcmp.202014008
Citation: SUN Mo, JIANG Zhihua, CHEN Shoutao. Effect of sitagliptin combined with rosiglitazone on glucose and lipid metabolism as well as insulin resistance in patients with type 2 diabetes[J]. Journal of Clinical Medicine in Practice, 2020, 24(14): 31-33. DOI: 10.7619/jcmp.202014008
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Effect of sitagliptin combined with rosiglitazone on glucose and lipid metabolism as well as insulin resistance in patients with type 2 diabetes

  • 1. Department of Emergency, 2. Department of Internal Medicine, Shanghai Electric Power Hospital, Shanghai, 200050

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  • Received Date: April 20, 2020
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  • Objective To observe the clinical efficacy of sitagliptin combined with rosiglitazone in treatment of patients with type 2 diabetes. Methods Totally 85 patients with type 2 diabetes were divided into control group(treated with routine treatment and rosiglitazone, n=42)and observation group(treated with routine treatment, rosiglitazone and sitagliptin, n=43), and both groups were treated for 2 months. Levels of fasting blood glucose, 2 h postprandial blood glucose, total cholesterol and triglyceride as well as insulin resistance index were compared between the two groups before treatment and after 2 months of treatment. Results After treatment, the levels of fasting blood glucose, 2 h postprandial blood glucose, total cholesterol and triglycerides in both groups were significantly lower than those before treatment, and the levels of indexes mentioned above in the observation group were significantly lower than those in the control group(P<0.05). After treatment, the insulin resistance index of the observation group was(4.06±0.97), which was significantly lower than(5.02±1.04)of the control group(P<0.05). Conclusion Sitagliptin combined with rosiglitazone is safe and effective in the treatment of patients with type 2 diabetes, which can reduce blood glucose and lipid levels and relieve insulin resistance.
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  • EDELMAN S V, POLONSKY W H. Response to comment on edelman and polonsky. Type 2 diabetes in the real world: the elusive nature of glycemic control[J]. Dia Care,2018, 41(2): e18-e26.
    SAMKANI A, SKYTTE M J, KANDEL D, et al. A carbohydrate-reduced high-protein diet acutely decreases postprandial and diurnal glucose excursions in type 2 diabetes patients[J]. Br J Nutr, 2018, 119(8): 910-917.
    郭建, 杨芳. 止渴养阴胶囊联合罗格列酮治疗2型糖尿病的临床研究[J]. 现代药物与临床, 2019, 34(9): 2786-2789.
    郝兆虎, 邵海琳, 黄霄, 等. 达格列净与西格列汀对胰岛素控制不佳的超重及肥胖2型糖尿病患者的疗效观察[J]. 中华糖尿病杂志, 2019, 11(9): 592-596.
    中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J]. 中华糖尿病杂志, 2018, 10(1): 4-67.
    KAMESWARAN V, GOLSON M L, RAMOS-RODRÍGUEZ M, et al. The dysregulation of the DLK1-MEG3 locus in islets from patients with type 2 diabetes is mimicked by targeted epimutation of its promoter with TALE-DNMT constructs[J]. Diabetes, 2018, 67(9): 1807-1815.
    杨华, 吴海清, 张艳. 强化降糖配合罗格列酮对老年冠心病合并2型糖尿病病人血脂和载脂蛋白的影响[J]. 蚌埠医学院学报, 2018, 43(6): 778-781.
    张建元, 秦婷婷, 尹平, 等. 二甲双胍与罗格列酮治疗2型糖尿病疗效和安全性的Meta分析[J]. 华中科技大学学报: 医学版, 2018, 47(1): 109-115.
    魏怡静, 薛威阳. 罗格列酮与格列美脲联合胰岛素治疗首次诊断2型糖尿病的临床效果比较[J]. 中国基层医药, 2017, 24(21): 3314-3317.
    卫欣欣, 赵文化. 西格列汀和阿卡波糖对胰岛素治疗控制不佳的2型糖尿病患者的疗效和安全性比较[J]. 中国药物与临床, 2019, 19(11): 1829-1831.
    吴金婵, 陈娟, 冯光球. 二甲双胍联合西格列汀或瑞格列奈治疗肥胖2型糖尿病患者的效果比较[J]. 中国医药, 2019, 14(5): 719-722.
    高婷婷. 西格列汀联合甘精胰岛素治疗老年2型糖尿病的疗效及对炎性因子的影响[J]. 中国药物与临床, 2019, 19(6): 969-971.
    阮芸, 姚佳琦, 王秀景, 等. 联用西格列汀治疗2型糖尿病患者腹腔内脏脂肪面积的变化[J]. 中华全科医师杂志, 2019, 18(11): 1081-1084.
    薛嫱, 邓晓慧, 宋丽清, 等. 老年2型糖尿病患者血脂与胰岛素抵抗及胰岛β细胞功能的关系[J]. 医学研究杂志, 2019, 48(5): 94-97

    , 133.
    刘佳, 杨伟, 魏占云, 等. 血脂异常与老年2型糖尿病患者轻度认知功能障碍的相关性[J]. 中华老年多器官疾病杂志, 2019, 18(12): 881-884.
    赵丹青, 鲁一兵, 左志华, 等. 西格列汀对胰岛素应用导致的2型糖尿病肥胖患者的干预效果和机制[J]. 现代仪器与医疗, 2017, 23(5): 66-67

    , 75.
    孔亚坤, 耿秀琴, 周艳红, 等. 甘精胰岛素与西格列汀联用治疗口服降糖药控制不佳的老年2型糖尿病的有效性和安全性[J]. 中国药师, 2016, 19(4): 695-697.
    刘福平, 张星光, 陈彬. 二甲双胍联合西格列汀或格列美脲对2型糖尿病血糖波动和氧化应激的影响[J]. 中国现代医学杂志, 2015, 25(33): 71-74.
    史春虹, 王璐, 白然, 等. 西格列汀和伏格列波糖分别联合实时动态胰岛素泵对新诊断2型糖尿病患者的疗效对比[J]. 中华医学杂志, 2016, 96(32): 2554-2558.
    王慧, 邝建, 罗涌, 等. 西格列汀对初治2型糖尿病患者胰岛素敏感性及胰岛α和β细胞功能的影响[J]. 中华糖尿病杂志, 2020, 12(6): 382-386.
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