Advance Search
ZHANG Fenhong, WEI Qing, ZHANG Ruirong, YANG Xiaojuan. Therapeutic effects of ambroxol hydrochloride combined with glucocorticoids in the treatment of idiopathic pulmonary fibrosis[J]. Journal of Clinical Medicine in Practice, 2020, 24(14): 56-59. DOI: 10.7619/jcmp.202014015
Citation: ZHANG Fenhong, WEI Qing, ZHANG Ruirong, YANG Xiaojuan. Therapeutic effects of ambroxol hydrochloride combined with glucocorticoids in the treatment of idiopathic pulmonary fibrosis[J]. Journal of Clinical Medicine in Practice, 2020, 24(14): 56-59. DOI: 10.7619/jcmp.202014015
shu

Therapeutic effects of ambroxol hydrochloride combined with glucocorticoids in the treatment of idiopathic pulmonary fibrosis

  • Pharmaceutical Department, Xi'an Daxing Hospital, Xi'an, Shaanxi, 710001

More Information
  • Received Date: March 20, 2020
    Graphical Abstract
    • Abstract
  • Objective To observe the effect of ambroxol hydrochloride combined with glucocorticoid in treatment of idiopathic pulmonary interstitial fibrosis(IPF). Methods A total of 100 patients with IPF were selected as subjects and divided into two groups according to the random number table method, with 50 cases in each group. Control group was treated with glucocorticoids, while observation group was treated with ambroxol hydrochloride combined with glucocorticoids. The clinical curative effect, lung function ［vital capacity(VC), forced vital capacity(FVC), forced expiratory volume(FEV), diffusion lung capacity for carbon monoxide(DLCO)］, levels of blood gas indicators such as arterial partial pressure of oxygen ［pa(O2)］, partial pressure of carbon dioxide in arterial blood ［pa(CO2)］, serum inflammatory factors ［interleukin-10(IL-10), interleukin-13(IL-13), transforming growth factor-β1(TGF-β1)］ and the incidence of adverse reactions were compared between the two groups. Results The total effectiverate of the observation group was 90.00%, which was significantly higher than 72.00% of the control group(P<0.05). After treatment, the VC, ratio of forced expiratory volume to forced vital capacity(FEV/FVC)and DLCO in the observation group were significantly higher than those in the control group(P<0.05). The pa(O2)in the observation group was significantly higher than that in the control group, and the pa(CO2)was significantly lower than that in the control group(P<0.05). Levels of serum IL-10, IL-13 and TGF-β1 in the observation group after treatment were significantly lower than those in the control group(P<0.05). The incidence of adverse reactions in the observation group was 8.00%, which was significantly lower - than 24.00% in the control group(P<0.05). Conclusion Ambroxol hydrochloride combined with glucocorticoids is effective in the treatment of IPF, which can improve respiratory function and reduce levels of inflammatory factors.
    • FullText(HTML)
    • References (18)
  • 胡蔓, 王建青. 通肺荡纤汤联合糖皮质激素治疗特发性肺间质纤维化疗效观察[J]. 现代中西医结合杂志, 2017, 26(9): 1002-1005.
    田牛, 王晓静, 王伟, 等. 重组人干扰素-γ与泼尼松联用治疗特发性肺间质纤维化的应用价值探究[J]. 临床肺科杂志, 2016, 21(1): 61-64.
    刘博, 张睿, 彭伟, 等. 盐酸氨溴索辅助治疗对慢性阻塞性肺疾病伴肺部感染患者肺功能和血气指标的影响[J]. 疑难病杂志, 2016, 15(10): 1020-1023.
    付建荣, 吴国斌. 盐酸氨溴索联合泼尼松治疗特发性肺间质纤维化临床观察[J]. 现代诊断与治疗, 2014, 25(18): 4175-4177.
    中华医学会呼吸病学分会. 特发性肺(间质)纤维化诊断和治疗指南[J]. 中华内科杂志, 2002, 25(7): 387-389.
    毛振兴. 吡非尼酮联合乙酰半胱氨酸治疗特发性肺间质纤维化的疗效观察[J]. 现代药物与临床, 2018, 33(8): 1969-1973.
    陈珊珊, 李华敏, 陈建寿, 等. 大剂量N-乙酰半胱氨酸联合糖皮质激素治疗慢性阻塞性肺疾病并肺间质纤维化的临床疗效[J]. 实用心脑肺血管病杂志, 2017, 25(3): 97-100.
    KREUTER M, WÄLSCHER J, BEHR J. Antifibrotic drugs as treatment of nonidiopathic pulmonary fibrosis interstitial pneumonias: the time is now[J]. Curr Opin Pulm Med, 2017, 23(5): 418-425.
    刘红, 万耘, 钟宏菊, 等. 盐酸氨溴索辅助治疗老年慢性阻塞性肺疾病的临床观察[J]. 中国药房, 2016, 27(15): 2048-2050.
    戴伟, 严骏, 胡朝梁, 等. 盐酸氨溴索对急性呼吸窘迫综合征大鼠肺纤维化及Wnt/β-catenin通路的影响[J]. 医学临床研究, 2018, 35(10): 1950-1953.
    PESONEN I, CARLSON L, MURGIA N, et al. Delay and inequalities in the treatment of idiopathic pulmonary fibrosis: the case of two Nordic countries[J]. Multidiscip Respir Med, 2018, 13: 14.
    谭毅. 盐酸氨溴索联合糖皮质激素治疗特发性肺间质纤维化的临床研究[J]. 临床合理用药杂志, 2013, 6(8): 8-9.
    邹文舟, 巩彦民. 盐酸氨溴索注射液联合酚妥拉明注射液治疗小儿重症肺炎的临床研究[J]. 现代中西医结合杂志, 2016, 25(2): 174-176.
    KAWAMURA K, ICHIKADO K, YASUDA Y, et al. Azithromycin for idiopathic acute exacerbation of idiopathic pulmonary fibrosis: a retrospective single-center study[J]. BMC Pulm Med, 2017, 17(1): 94.
    HUANG X Y, HE Y C, CHEN Y F, et al. Baicalin attenuates bleomycin-induced pulmonary fibrosis via adenosine A2a receptor related TGF-β1-induced ERK1/2 signaling pathway[J]. BMC Pulm Med, 2016, 16(1): 132.
    潘勇军, 刘红霞. 银杏叶提取物联合糖皮质激素治疗特发性肺纤维化疗效及对血清TGF-β1、IL-13、SOD、MDA的影响[J]. 现代中西医结合杂志, 2017, 26(21): 2312-2315.
    陈天明, 杨锁平, 卢青, 等. 益气活血调补肺肾法对肺间质纤维化患者肺功能及血清IL-13、TGF-β含量的影响[J]. 中医药导报, 2017, 23(9): 100-102.
    樊茂蓉, 韩克华, 王冰, 等. 通肺络补宗气方对特发性肺间质纤维化患者血清TGF-β、TNF-α、CTGF及PDGF的影响[J]. 辽宁中医杂志, 2017, 44(12): 2572-2575.
    • Related Articles

Catalog

    Get Citation
    PDF
    XML
    Article views (501) PDF downloads (20) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return