Correlation between early-onset sepsis and brain injury in late preterm infants

LUO Wenli; ZHAO Yang

doi:10.7619/jcmp.20201426

Journal of Clinical Medicine in Practice > 2021 > 25(3): 51-53, 58. > DOI: 10.7619/jcmp.20201426

LUO Wenli, ZHAO Yang. Correlation between early-onset sepsis and brain injury in late preterm infants[J]. Journal of Clinical Medicine in Practice, 2021, 25(3): 51-53, 58. DOI: 10.7619/jcmp.20201426

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Correlation between early-onset sepsis and brain injury in late preterm infants

LUO Wenli¹,
ZHAO Yang^2, ,

1.
Postgraduate Training Base, Shiyan City People′s Hospital of Jinzhou Medical University, Shiyan, Hubei, 442000
2.
Department of Neonatology, Shiyan City People′s Hospital Affiliated to Hubei University of Medicine, Shiyan, Hubei, 442000

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Received Date: November 10, 2020
Available Online: March 03, 2021
Published Date: March 03, 2021

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Abstract

Abstract

Objective To observe the clinical manifestations of early-onset sepsis complicated with brain injury in late preterm infants (LPI).
Methods Totally 423 hospitalized infants with LPI in Department of Neonatology were selected, among which the infants with sepsis were designed as observation group(n=104), and the infants without sepsis were designed as control group(n=319). The general situation, clinical manifestations, change of magnetic resonance imaging (MRI), treatment and outcome as well as score of 28-day Neonatal Behavioral Neurological Assessment (NBNA) were compared between the two groups.
Results The incidence rates of apnea, hypotension and brain white matter injury in the observation group were significantly higher than those in the control group (P < 0.05). The time of invasive mechanical ventilation and hospital stay were significantly longer of the infants with brain injury in the observation group, incidence of neonatal necrotizing enterocolitis (NEC) and abnormal rate of NBNA were significantly higher than those in the control group (P < 0.05).
Conclusion LPI with early-onset sepsis is more prone to brain injury, and the incidence of complications in hospital and abnormal rate of NBNA score are higher.

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