Kuntai Capsule versus femoston in the treatment of patients with climacteric syndrome

Objective To compare the effect of Kuntai Capsule and femoston in the treatment of patients with climacteric syndrome. Methods Totally 80 patients with climacteric syndrome were randomly divided into observation group(n=40)and control group(n=40). The control group was treated with femoston, and the observation group was treated with Kuntai Capsule. The levels of blood lipid indexes ［triglyceride(TG), high density lipoprotein cholesterol(HDL-C), total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)］, sex hormone indexes ［estradiol(E₂), luteinizing hormone(LH)and follicle stimulating hormone(FSH)］ and adverse reactions were compared before and after treatment between the two groups. Results After 12 weeks of treatment, the levels of TG, TC, LDL-C and HDL-C in both groups were significantly improved, the levels of TG, TC, LDL-C in the observation group were significantly lower than those in the control group, and the HDL-C level was significantly higher than that in the control group(P<0.05). After 12 weeks of treatment, the levels of E₂, LH and FSH in both groups were significantly improved when compared with those before treatment, and the level of E₂ in the observation group was significantly higher than that in the control group, while the levels of LH and FSH were significantly lower than those in the control group(P<0.05). The incidence of adverse reactions in the observation group was 7.50%, which showed no significant difference compared to 17.50% in the control group(P>0.05). Conclusion Clinical effect of Kuntai Capsule is significantly better than that of femoston in the treatment of patients with climacteric syndrome, which can not only effectively regulate the levels of blood lipid indexes and sex hormone indexes, but also has less adverse reactions.