Effects of different estrogen administration regimens on recurrence of adhesion after hysteroscopic surgery in patients with moderate to severe intrauterine adhesions

Objective  To explore the effects of two different estrogen regimens on the recurrence of postoperative adhesions and endometrial growth in patients with moderate to severe intrauterine adhesion(IUA).   Methods  A total of 82 patients were divided into femoston group and progynova group by simple random method, with 41 cases in each group. The effects of menstruation recovery, endometrial morphology recovery, endometrial thickness and serum estradiol(E₂)changes in the two groups were observed. Follow up for 6 months after treatment, the recurrence of intrauterine adhesions was compared between the two groups.   Results  After 2 months of treatment, the total effective rate of menstrual recovery was 95.12% in the femoston group, which was significantly higher than 80.49% in the progynova group(P<0.05); the proportion of type A uterine cavity morphology in the femoston group was 78.05%, which was significantly higher than 56.10% in the progynova group(P<0.05); endometrial thickness and serum E₂ level were significantly higher after treatment than treatment before(P<0.05); after treatment, endometrial thickness and serum E₂ level in the femoston group were significantly higher than those in the progynova group(P<0.05); at 6 months after the operation, the recurrence rate of adhesions in the femoston group was 7.32%, which was significantly lower than 24.39% - in the progynova group(P<0.05).   Conclusion  Femoston can effectively improve the menstrual recovery and uterine cavity shape, promote endometrial growth, reduce the rate of adhesion and recurrence after hysteroscopy, and the clinical effect is better than that of progynova.