Research progress on the correlation between premature ovarian failure and abnormal expansion repeat of CGG of the fragile X mental retardation 1

DONG Yan

doi:10.7619/jcmp.20201732

Journal of Clinical Medicine in Practice > 2021 > 25(4): 121-124. > DOI: 10.7619/jcmp.20201732

DONG Yan. Research progress on the correlation between premature ovarian failure and abnormal expansion repeat of CGG of the fragile X mental retardation 1[J]. Journal of Clinical Medicine in Practice, 2021, 25(4): 121-124. DOI: 10.7619/jcmp.20201732

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Research progress on the correlation between premature ovarian failure and abnormal expansion repeat of CGG of the fragile X mental retardation 1

DONG Yan

Department of Reproductive Health, Tianjin First Central Hospital, Tianjin, 300192

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Received Date: December 19, 2020
Available Online: March 14, 2021
Published Date: February 27, 2021

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Abstract

Abstract

Fragile X syndrome (FXS) is often manifested as a multisystem disorder such as inherited intellectual disabilities and autism. Fragile X mental retardation 1 (FMR1) is an important genetic factor associated with premature ovarian failure (POF). Female with POF still have a certain probability of getting pregnant, and carriers with abnormal expansion repeat of CGG of FMR1 gene more likely occur. It leads to changes in reproductive function and an increased incidence of unexplained recurrent miscarriages in patients with POF. This paper reviewed the studies on premature ovarian failure and abnormal expansion repeat of CGG of FMR1, and provided a theoretical basis for genetic counseling and fertility guidance, so as to reduce birth defects.
- premature ovarian failure,
- fragile X mental retardation 1,
- repeated sequence,
- birth defects

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References

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