Research progress of targeted therapy for cervical cancer by tumor-associated macrophages

LU Hangcheng; WEI Weiwei; CHEN Jiming; SHI Ruxia

doi:10.7619/jcmp.20201759

Journal of Clinical Medicine in Practice > 2021 > 25(7): 123-127, 132. > DOI: 10.7619/jcmp.20201759

LU Hangcheng, WEI Weiwei, CHEN Jiming, SHI Ruxia. Research progress of targeted therapy for cervical cancer by tumor-associated macrophages[J]. Journal of Clinical Medicine in Practice, 2021, 25(7): 123-127, 132. DOI: 10.7619/jcmp.20201759

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Research progress of targeted therapy for cervical cancer by tumor-associated macrophages

Department of Gynecology, The Second People's Hospital of Changzhou City Affiliated to Nanjing Medical University, Changzhou, Jiangsu, 213000

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Received Date: December 21, 2020
Available Online: April 20, 2021
Published Date: April 14, 2021

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Abstract

Abstract

Tumor associated macrophages (TAM) are important immune cells in the tumor microenvironment (TME), which can secrete a variety of cytokines to participate in and regulate the biological behavior of cervical cancer (CC). A detailed understanding of the mechanism of TAM affecting the growth and metastasis of CC is the key to the development of targeted therapies. In this paper, the progress of TAM treatment in CC was reviewed in recent years, and the potential therapeutic targets, vaccines and drugs for TAM targeted treatment of CC were mainly discussed, which may provide theoretical basis for the research and development of novel targeted drugs for CC, in order to improve the quality of life and prolong the survival time of patients.
- cervical cancer,
- tumor-associated macrophages,
- immunotherapy,
- phenotypic transformation,
- vaccine

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