Effect of Yangxin Anshen Decoction on sleep in patients with schizophrenia complicating with sleep disturbance

LIU Dan; SUN Jianping; PANG Mengjiao; CHEN Wenyun

doi:10.7619/jcmp.20201815

Journal of Clinical Medicine in Practice > 2021 > 25(7): 67-70. > DOI: 10.7619/jcmp.20201815

LIU Dan, SUN Jianping, PANG Mengjiao, CHEN Wenyun. Effect of Yangxin Anshen Decoction on sleep in patients with schizophrenia complicating with sleep disturbance[J]. Journal of Clinical Medicine in Practice, 2021, 25(7): 67-70. DOI: 10.7619/jcmp.20201815

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Effect of Yangxin Anshen Decoction on sleep in patients with schizophrenia complicating with sleep disturbance

Department of Psychiatry, Zhangjiagang Mental Health Center of Jiangsu Province, Zhangjiagang Fourth People's Hospital of Jiangsu Province, Zhangjiagang, Jiangsu, 215600

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Received Date: December 27, 2020
Available Online: April 20, 2021
Published Date: March 31, 2021

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Abstract

Abstract

Objective To investigate the effect of Yangxin Anshen Decoction on sleep structure and sleep quality in patients with schizophrenia with sleep disturbance.
Methods Eighty-six patients with schizophrenia with sleep disorder were randomly divided into control group and observation group, with 43 cases in each group. The control group was treated with conventional western medicine, and the observation group was treated with Yangxin Anshen Decoction on the basis of the control group. Clinical efficacy, TCM syndrome score, sleep quality, sleep structure and incidence of adverse reactions were compared between the two groups.
Results The total effective rate of the observation group was 88.37%, which was significantly higher than 69.77% of the control group (P < 0.05). After treatment, the scores of primary syndrome, secondary syndrome and Pittsburgh Sleep Quality Index (PSQI) in the two groups were significantly lower than those before treatment, and were significantly lower in the observation group than the control group (P < 0.05); the time of stage 1 (S1) and stage 2 (S2) of non-rapid eye movement sleep in the two groups were significantly shorter than those before treatment, and were significantly shorter in the observation group than the control group (P < 0.05); the time of the third (S3) and fourth (S4) stages of non-rapid eye movement sleep as well as the time of rapid eye movement in the two groups were significantly longer than those in the control group, and were significantly longer in the observation group than the control group (P < 0.05). There was no statistical significance in the incidence of adverse reactions between the two groups (P>0.05).
Conclusion Yangxin Anshen Decoction combined with conventional western medicine can effectively improve the clinical efficacy of in patients with schizophrenia with sleep disturbance, improve their sleep structure and sleep quality, and has higher safety.
- Yangxin Anshen Decoction,
- schizophrenia,
- sleep disorders,
- sleep structure,
- sleep quality

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